| Gene Symbol | Il4r |
|---|---|
| Entrez Gene | 25084 |
| Alt Symbol | Il4ra |
| Species | Rat |
| Gene Type | protein-coding |
| Description | interleukin 4 receptor |
| Other Description | IL-4 receptor subunit alpha|IL-4R subunit alpha|IL-4R-alpha|IL-4RA|interleukin 4 receptor, alpha|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha |
| Swissprots | Q63257 Q9WTM8 Q9R1W8 |
| Accessions | EDM17513 EDM17514 EDM17515 EDM17516 Q63257 AB015746 BAA78337 AB015747 BAA78338 AW527353 BQ204155 X69903 CAA49528 XM_006230215 XP_006230277 XM_006230216 XP_006230278 XM_008759862 XP_008758084 XM_008759863 XP_008758085 XM_008759864 XP_008758086 NM_133380 NP_596871 |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Isoform 2 is expressed in kidney, spleen, lung and liver. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD) |