Gene Symbol | Il4r |
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Entrez Gene | 25084 |
Alt Symbol | Il4ra |
Species | Rat |
Gene Type | protein-coding |
Description | interleukin 4 receptor |
Other Description | IL-4 receptor subunit alpha|IL-4R subunit alpha|IL-4R-alpha|IL-4RA|interleukin 4 receptor, alpha|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha |
Swissprots | Q63257 Q9WTM8 Q9R1W8 |
Accessions | EDM17513 EDM17514 EDM17515 EDM17516 Q63257 AB015746 BAA78337 AB015747 BAA78338 AW527353 BQ204155 X69903 CAA49528 XM_006230215 XP_006230277 XM_006230216 XP_006230278 XM_008759862 XP_008758084 XM_008759863 XP_008758085 XM_008759864 XP_008758086 NM_133380 NP_596871 |
Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Isoform 2 is expressed in kidney, spleen, lung and liver. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD) |
Rat Interleukin 4 Receptor Protein - abx067534 from Abbexa
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Interleukin 4 Receptor (IL4R), Rat - 20-8288 from ARP American Research Products
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Recombinant Rat Il4r, Fc tagged - Il4r-379R from Creative Biomart
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Recombinant Rat Il4ra, His tagged - Il4ra-7458R from Creative Biomart
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Rat IL4R / Il4ra Protein (Fc Tag) - 80198-R02H-100 from Sino Biological
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Rat IL4R / Il4ra Protein (His Tag) - 80198-R08H-50 from Sino Biological
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Recombinant Interleukin 4 Receptor (IL4R) - RPC031Ra01 from Cloud-clone
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Recombinant Rat Interleukin-4 receptor subunit alpha(Il4r) - CSB-YP717364RA CSB-EP717364RA CSB-BP717364RA CSB-MP717364RA from Cusabio
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Interleukin 4 Receptor (IL4R) - RPU142306 from Biomatik
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Recombinant Rat IL4R / Il4ra Protein (His tag) - PKSR030322 from Elabscience
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Recombinant Rat IL4R / Il4ra Protein (Fc tag) - PKSR030323 from Elabscience
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Recombinant Rat IL4RA Protein - IL4RA-3048R from Creative Biomart
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Recombinant Interleukin 4 Receptor (IL4R) - RPU42306 from Biomatik
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IL4R Recombinant Protein (OPCD04431) - OPCD04431 from Aviva Systems Biology
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Rat IL4R / Il4ra Protein (His Tag) - 80198-R08H from ABclonal
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IL4R / Il4ra, Recombinant Protein - MBS2547428 from MyBioSource
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IL4R / Il4ra, Recombinant Protein - MBS2547429 from MyBioSource
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Interleukin 4 Receptor (IL4R), Recombinant Protein - MBS2010189 from MyBioSource
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Interleukin-4 receptor subunit alpha (Il4r), Recombinant Protein - MBS1375403 from MyBioSource
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