| Gene Symbol |
RFX6
|
| Entrez Gene |
222546
|
| Alt Symbol |
MTCHRS, MTFS, RFXDC1, dJ955L16.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulatory factor X, 6
|
| Other Description |
DNA-binding protein RFX6|regulatory factor X domain-containing protein 1
|
| Swissprots |
Q5T6B3 Q8HWS3
|
| Accessions |
EAW48212 EAW48213 Q8HWS3 BC039248 AAH39248 BQ269808 CA842450 CA947154 XM_011535589 XP_011533891 NM_173560 NP_775831
|
| Function |
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. {ECO:0000269|PubMed:20148032}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00858}.
|
| Tissue Specificity |
Specifically expressed in pancreas, small intestine and colon. {ECO:0000269|PubMed:20148032}.
|
![Western Blot: RFX6 Overexpression Lysate (Adult Normal) [NBP2-05116] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RFX6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24235_RFX6%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05116-img0001.jpg)