RFX6

Gene Symbol RFX6
Entrez Gene 222546
Alt Symbol MTCHRS, MTFS, RFXDC1, dJ955L16.1
Species Human
Gene Type protein-coding
Description regulatory factor X, 6
Other Description DNA-binding protein RFX6|regulatory factor X domain-containing protein 1
Swissprots Q5T6B3 Q8HWS3
Accessions EAW48212 EAW48213 Q8HWS3 BC039248 AAH39248 BQ269808 CA842450 CA947154 XM_011535589 XP_011533891 NM_173560 NP_775831
Function Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. {ECO:0000269|PubMed:20148032}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00858}.
Tissue Specificity Specifically expressed in pancreas, small intestine and colon. {ECO:0000269|PubMed:20148032}.

RFX6 CRISPR/Cas9 KO Plasmid (h) - sc-408496 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 HDR Plasmid (h) - sc-408496-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 Double Nickase Plasmid (h) - sc-408496-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 Double Nickase Plasmid (h2) - sc-408496-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 CRISPR Activation Plasmid (h) - sc-408496-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 CRISPR Activation Plasmid (h2) - sc-408496-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 Lentiviral Activation Particles (h) - sc-408496-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 Lentiviral Activation Particles (h2) - sc-408496-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RFX6 siRNA (h) - sc-95649 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RFX6 shRNA Plasmid (h) - sc-95649-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RFX6 shRNA (h) Lentiviral Particles - sc-95649-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RFX6 RNAi - H00222546-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU032361 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18189 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18189 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RFX6 siRNA (Human) - CRJ6569 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RFX6 - MBS8236429 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RFX6 (NM_173560.3) - SHH392448 from Creative biogene

Category siRNA
Species Reactivities Human

Human RFX6 siRNA - orb277070 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RFX6 shRNA Plasmid (Human) - CHJ6569 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RFX6 miRNA 3'UTR clone - MiUTR3H-12536 from Creative biogene

Species Reactivities Human
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