ENAH

Gene Symbol	ENAH
Entrez Gene	55740
Alt Symbol	ENA, MENA, NDPP1
Species	Human
Gene Type	protein-coding
Description	enabled homolog (Drosophila)
Other Description	mammalian enabled variant 11a|mammalian enabled variant pan|protein enabled homolog
Swissprots	Q9UFB8 Q502W5 Q8N8S7 Q9NVF3 Q5VTR0 Q5VTQ9 Q5T5M7 D0PQI2
Accessions	CCG13846 EAW69747 Q8N8S7 AF519769 AAQ08487 AK001635 BAA91799 AK025108 AK096246 BAC04736 AK126894 BAC86739 AK127561 BAC87036 AK290179 BAF82868 AL133059 CAB61384 AY345143 AAR04685 BC010414 BC037319 BC065238 AAH65238 BC095481 AAH95481 BQ672102 CB961874 CB991931 EU255274 ABY78022 KM214203 AIU47267 KM214204 AIU47268 XM_005273187 XP_005273244 XM_006711795 XP_006711858 XM_006711796 XP_006711859 XM_006711797 XP_006711860 XM_011544229 XP_011542531 XM_011544230 XP_011542532 XM_011544231 XP_011542533 XM_011544232 XP_011542534 XM_011544233 XP_011542535 XM_011544234 XP_011542536 XM_011544235 XP_011542537 NM_001008493 NP_001008493 NM_018212 NP_060682
Function	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. {ECO:0000269|PubMed:15027125}.
Top Pathways	Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mena (D33C1) Rabbit mAb - 6921 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D33C1

Mena Antibody - 2075 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Mena (S-20) - sc-9466 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Mena (K-16) - sc-9467 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Mena (H-58) - sc-366150 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Mena (21) - sc-135988 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-ENAH / MENA Antibody (aa446-475) - LS-C159530 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (Internal, clone EPR5660) IHC-plus™ - LS-B11390 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EPR5660

Anti-ENAH / MENA Antibody (aa446-475, AP) - LS-C234948 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa446-475, APC) - LS-C234949 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa446-475, FITC) - LS-C234951 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa446-475, Biotin) - LS-C234950 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa446-475, PE) - LS-C234953 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa446-475, Azide-free, HRP) - LS-C249909 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa541-591) - LS-C288294 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa450-500) - LS-C288293 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa291-391) - LS-C307399 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ENAH / MENA Antibody (aa446-475) - LS-C329499 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa472-521) - LS-C120255 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ENAH / MENA Antibody (aa671-720) - LS-C170270 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Mena Antibody - AF5304 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Mena Antibody - NBP1-87914 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Mena Antibody - NBP1-87915 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Mena Antibody - 45940002 from Novus Biologicals Prices $299.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Mena Antibody (3E6) - H00055740-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E6

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