ENAH

Gene Symbol ENAH
Entrez Gene 55740
Alt Symbol ENA, MENA, NDPP1
Species Human
Gene Type protein-coding
Description enabled homolog (Drosophila)
Other Description mammalian enabled variant 11a|mammalian enabled variant pan|protein enabled homolog
Swissprots Q9UFB8 Q502W5 Q8N8S7 Q9NVF3 Q5VTR0 Q5VTQ9 Q5T5M7 D0PQI2
Accessions CCG13846 EAW69747 Q8N8S7 AF519769 AAQ08487 AK001635 BAA91799 AK025108 AK096246 BAC04736 AK126894 BAC86739 AK127561 BAC87036 AK290179 BAF82868 AL133059 CAB61384 AY345143 AAR04685 BC010414 BC037319 BC065238 AAH65238 BC095481 AAH95481 BQ672102 CB961874 CB991931 EU255274 ABY78022 KM214203 AIU47267 KM214204 AIU47268 XM_005273187 XP_005273244 XM_006711795 XP_006711858 XM_006711796 XP_006711859 XM_006711797 XP_006711860 XM_011544229 XP_011542531 XM_011544230 XP_011542532 XM_011544231 XP_011542533 XM_011544232 XP_011542534 XM_011544233 XP_011542535 XM_011544234 XP_011542536 XM_011544235 XP_011542537 NM_001008493 NP_001008493 NM_018212 NP_060682
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. {ECO:0000269|PubMed:15027125}.
Top Pathways Regulation of actin cytoskeleton

Mena CRISPR/Cas9 KO Plasmid (h) - sc-405484 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena HDR Plasmid (h) - sc-405484-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena Double Nickase Plasmid (h) - sc-405484-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena Double Nickase Plasmid (h2) - sc-405484-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena CRISPR Activation Plasmid (h) - sc-405484-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena CRISPR Activation Plasmid (h2) - sc-405484-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena Lentiviral Activation Particles (h) - sc-405484-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena Lentiviral Activation Particles (h2) - sc-405484-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mena siRNA (h) - sc-43496 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mena shRNA Plasmid (h) - sc-43496-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mena shRNA (h) Lentiviral Particles - sc-43496-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7862 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7862 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ENAH siRNA (Human) - CRJ0878 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ENAH - MBS8212712 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ENAH (NM_001008493.1) - SHH285701 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ENAH(NM_018212.4) - SHH033293 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ENAH(NM_001008493.1) - SHH033383 from Creative biogene

Category siRNA
Species Reactivities Human

ENAH shRNA Plasmid (Human) - CHJ0878 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ENAH miRNA 3'UTR clone - MiUTR1H-03222 from Creative biogene

Species Reactivities Human

ENAH miRNA 3'UTR clone - MiUTR1H-03223 from Creative biogene

Species Reactivities Human
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