STEAP3

Gene Symbol STEAP3
Entrez Gene 55240
Alt Symbol AHMIO2, STMP3, TSAP6, dudlin-2
Species Human
Gene Type protein-coding
Description STEAP family member 3, metalloreductase
Other Description 1010001D01Rik|dudlin 2|dudulin 2|dudulin-2|hTSAP6|hpHyde|metalloreductase STEAP3|pHyde|six transmembrane prostate protein 3|six-transmembrane epithelial antigen of prostate 3|tumor suppressor pHyde|tumor suppressor-activated pathway protein 6
Swissprots Q4ZG36 Q8TDP3 Q4VBR2 Q53SQ8 A8K6E3 Q9NVB5 Q86SF6 Q8TF03 Q8NEW6 Q658P3 Q7Z389
Accessions AAX88963 AAY14872 EAW95209 EAW95210 EAW95211 EAW95212 Q658P3 AF238864 AAL78206 AF262322 AAM08128 AF423424 AAQ04065 AK001691 BAA91839 AK024163 BAB14842 AK291608 BAF84297 AL833624 CAH56204 AM392543 CAL37421 AY029585 AAK50538 AY082673 AAM45136 AY214461 AAO38238 BC042150 AAH42150 BC095421 AAH95421 BM146930 BX538047 CAD97986 XM_006712614 XP_006712677 XM_006712615 XP_006712678 XM_011511403 XP_011509705 NM_001008410 NP_001008410 NM_018234 NP_060704 NM_182915 NP_878919
Function Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434}.
Subcellular Location Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
Tissue Specificity Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15885357, ECO:0000269|PubMed:16227996}.
Top Pathways p53 signaling pathway

pHyde (H-4) - sc-376327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pHyde (H-4): sc-376327. Western blot analysis of pHyde expression in human liver tissue extract (A) and HeLa whole cell lysate (B).

pHyde (N-15) - sc-103884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

pHyde (R-20) - sc-20533 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

pHyde (H-64) - sc-292255 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
pHyde (H-64): sc-292255. Western blot analysis of pHyde expression in Hep G2 nuclear extract.

pHyde (T-20) - sc-20531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
pHyde (T-20): sc-20531. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-STEAP3 antibody - ab72513 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STEAP3 antibody (ab72513) at 1/500 dilutionLane 1 : COLO205 cell extractLane 2 : COLO205 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-STEAP3 antibody - ab126068 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-STEAP3 antibody (ab126068) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-STEAP3 antibody [EPR9812] - ab151566 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9812
All lanes : Anti-STEAP3 antibody [EPR9812] (ab151566) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : PC12 cell lysateLane 4 : C6 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-STEAP3 antibody - N-terminal - ab180770 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-STEAP3 antibody - N-terminal (ab180770) at 1/500 dilutionLane 1 : ES 2 cell line lysateLane 2 : Mouse liver tissue lysateLane 3 : Mouse heart tissue lysate

Anti-TSAP6 / STEAP3 Antibody (N-Terminus) IHC-plus™ - LS-B1406 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-STEAP3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1406 concentration 5 ug/ml.

Anti-TSAP6 / STEAP3 Antibody (aa411-460) - LS-C80575 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal liver cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-TSAP6 / STEAP3 Antibody (aa47-96) - LS-C80581 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-TSAP6 / STEAP3 Antibody (aa441-470, AP) - LS-C224177 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa441-470, Biotin) - LS-C224179 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa441-470, APC) - LS-C224178 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa441-470, FITC) - LS-C224180 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa441-470, Azide-free, HRP) - LS-C224181 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa441-470, PE) - LS-C224182 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody (aa440-470) - LS-C325445 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSAP6 / STEAP3 Antibody - LS-C192254 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of STEAP3 pAb in extracts from HepG2 cells.

Anti-TSAP6 / STEAP3 Antibody (aa441-470) - LS-C161557 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
STEAP3 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The STEAP3 antibody detected the STEAP3 protein (arrow).

Anti-TSAP6 / STEAP3 Antibody (aa421-470) - LS-C119102 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using STEA3 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-TSAP6 / STEAP3 Antibody - LS-C331063 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using STEAP3 antibody.

STEAP3/TSAP6 Antibody - NB100-80830 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: STEAP3 Antibody [NB100-80830] - Rat liver tissue lysate.

STEAP3/TSAP6 Antibody - NBP1-76824 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: STEAP3/TSAP6 Antibody [NBP1-76824] - Rat liver tissue lysate with STEAP3 antibody at (A) 1 and (B) 2 ug/mL.
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