STEAP3

Gene Symbol	STEAP3
Entrez Gene	55240
Alt Symbol	AHMIO2, STMP3, TSAP6, dudlin-2
Species	Human
Gene Type	protein-coding
Description	STEAP family member 3, metalloreductase
Other Description	1010001D01Rik|dudlin 2|dudulin 2|dudulin-2|hTSAP6|hpHyde|metalloreductase STEAP3|pHyde|six transmembrane prostate protein 3|six-transmembrane epithelial antigen of prostate 3|tumor suppressor pHyde|tumor suppressor-activated pathway protein 6
Swissprots	Q4ZG36 Q8TDP3 Q4VBR2 Q53SQ8 A8K6E3 Q9NVB5 Q86SF6 Q8TF03 Q8NEW6 Q658P3 Q7Z389
Accessions	AAX88963 AAY14872 EAW95209 EAW95210 EAW95211 EAW95212 Q658P3 AF238864 AAL78206 AF262322 AAM08128 AF423424 AAQ04065 AK001691 BAA91839 AK024163 BAB14842 AK291608 BAF84297 AL833624 CAH56204 AM392543 CAL37421 AY029585 AAK50538 AY082673 AAM45136 AY214461 AAO38238 BC042150 AAH42150 BC095421 AAH95421 BM146930 BX538047 CAD97986 XM_006712614 XP_006712677 XM_006712615 XP_006712678 XM_011511403 XP_011509705 NM_001008410 NP_001008410 NM_018234 NP_060704 NM_182915 NP_878919
Function	Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434}.
Subcellular Location	Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
Tissue Specificity	Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15885357, ECO:0000269|PubMed:16227996}.
Top Pathways	p53 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STEAP3 overexpression lysate - LY405328 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

STEAP3/TSAP6 Overexpression Lysate (Native) - NBP2-08809 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

STEAP3/TSAP6 Overexpression Lysate (Native) - NBP2-09123 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

STEAP3/TSAP6 Overexpression Lysate (Native) - NBP2-06848 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human STEAP3 Knockdown Stable Cell Line - CSC-DC015295 from Creative biogene Category Cell Line Species Human

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