STEAP3
| Gene Symbol | STEAP3 |
|---|---|
| Entrez Gene | 55240 |
| Alt Symbol | AHMIO2, STMP3, TSAP6, dudlin-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | STEAP family member 3, metalloreductase |
| Other Description | 1010001D01Rik|dudlin 2|dudulin 2|dudulin-2|hTSAP6|hpHyde|metalloreductase STEAP3|pHyde|six transmembrane prostate protein 3|six-transmembrane epithelial antigen of prostate 3|tumor suppressor pHyde|tumor suppressor-activated pathway protein 6 |
| Swissprots | Q4ZG36 Q8TDP3 Q4VBR2 Q53SQ8 A8K6E3 Q9NVB5 Q86SF6 Q8TF03 Q8NEW6 Q658P3 Q7Z389 |
| Accessions | AAX88963 AAY14872 EAW95209 EAW95210 EAW95211 EAW95212 Q658P3 AF238864 AAL78206 AF262322 AAM08128 AF423424 AAQ04065 AK001691 BAA91839 AK024163 BAB14842 AK291608 BAF84297 AL833624 CAH56204 AM392543 CAL37421 AY029585 AAK50538 AY082673 AAM45136 AY214461 AAO38238 BC042150 AAH42150 BC095421 AAH95421 BM146930 BX538047 CAD97986 XM_006712614 XP_006712677 XM_006712615 XP_006712678 XM_011511403 XP_011509705 NM_001008410 NP_001008410 NM_018234 NP_060704 NM_182915 NP_878919 |
| Function | Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434}. |
| Subcellular Location | Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. |
| Tissue Specificity | Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15885357, ECO:0000269|PubMed:16227996}. |
| Top Pathways | p53 signaling pathway |
pHyde CRISPR/Cas9 KO Plasmid (h) - sc-405526 from Santa Cruz Biotechnology
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pHyde HDR Plasmid (h) - sc-405526-HDR from Santa Cruz Biotechnology
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pHyde Double Nickase Plasmid (h) - sc-405526-NIC from Santa Cruz Biotechnology
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pHyde Double Nickase Plasmid (h2) - sc-405526-NIC-2 from Santa Cruz Biotechnology
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pHyde CRISPR Activation Plasmid (h) - sc-405526-ACT from Santa Cruz Biotechnology
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pHyde CRISPR Activation Plasmid (h2) - sc-405526-ACT-2 from Santa Cruz Biotechnology
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pHyde Lentiviral Activation Particles (h) - sc-405526-LAC from Santa Cruz Biotechnology
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pHyde Lentiviral Activation Particles (h2) - sc-405526-LAC-2 from Santa Cruz Biotechnology
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pHyde siRNA (h) - sc-37487 from Santa Cruz Biotechnology
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pHyde shRNA Plasmid (h) - sc-37487-SH from Santa Cruz Biotechnology
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pHyde shRNA (h) Lentiviral Particles - sc-37487-V from Santa Cruz Biotechnology
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STEAP3/TSAP6 RNAi - H00055240-R01 from Novus Biologicals
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STEAP3/TSAP6 RNAi - H00055240-R03 from Novus Biologicals
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MISSION® esiRNA - EHU125031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20721 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12882 from Sigma-Aldrich
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STEAP3 siRNA (Human) - CRJ0587 from Cohesion Biosciences
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STEAP3/TSAP6 RNAi - H00055240-R02 from Novus Biologicals
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STEAP3 - MBS8230582 from MyBioSource
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shRNA set against Human STEAP3 (NM_182915.2) - SHH419572 from Creative biogene
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shRNA set against Human STEAP3(NM_182915.2) - SHL033606 from Creative biogene
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shRNA set against Human STEAP3(NM_001008410.1) - SHL033624 from Creative biogene
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STEAP3 shRNA Plasmid (Human) - CHJ0587 from Cohesion Biosciences
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STEAP3 miRNA 3'UTR clone - MiUTR1H-09994 from Creative biogene
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