GTF2I

Gene Symbol GTF2I
Entrez Gene 2969
Alt Symbol BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
Species Human
Gene Type protein-coding
Description general transcription factor IIi
Other Description BTK-associated protein, 135kD|Bruton tyrosine kinase-associated protein 135|SRF-Phox1-interacting protein|Williams-Beuren syndrome chromosome region 6|general transcription factor II-I
Swissprots Q75M88 Q75M85 Q75M87 Q75M86 O15359 Q9BSZ4 Q86U51 O14743 O43588 O43546 P78347 O43589
Accessions AAL93085 AAS07460 AAS07461 AAS07462 AAS07463 AAS07464 EAW69594 EAW69595 EAW69596 EAW69597 EAW69598 P78347 AA641906 AF015553 AAB70791 AF035737 AAC08312 AF038967 AAC08313 AF038968 AAC08314 AF038969 AAC08315 AK057670 AK093663 AK096095 AK292832 BAF85521 AK294935 BAG58013 AK297238 BAG59719 BC004472 AAH04472 BC070484 AAH70484 BC099907 AAH99907 BT007450 AAP36118 CB118501 DC346283 KJ534859 AHW56499 KJ534860 AHW56500 KJ534861 AHW56501 KJ534862 AHW56502 KJ534863 AHW56503 KJ534965 AHW56605 U77948 AAB48826 Y14946 CAA75163 XM_011516110 XP_011514412 XR_927460 NM_001163636 NP_001157108 NM_001280800 NP_001267729 NM_001518 NP_001509 NM_032999 NP_127492 NM_033000 NP_127493 NM_033001 NP_127494
Function Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.
Tissue Specificity Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
Top Pathways Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors

TFII-I Antibody - 4562 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, HEK293, U-937, COS, C2C12 and WEHI-231 cells, using TFII-I Antibody.

TFII-I (B-7) - sc-46670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TFII-I (B-7): sc-46670. Immunoperoxidase staining of formalin fixed, paraffin-embedded human salivary gland tissue showing nuclear staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

TFII-I (H-58) - sc-28716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TFII-I (H-58): sc-28716. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TFII-I (N-18) - sc-9944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TFII-I (N-18): sc-9944. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TFII-I (V-18) - sc-9943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TFII-I (V-18): sc-9943. Immunofluorescence staining of methanol-fixed HeLa cells (A) and immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tumor (B) showing nuclear localization.

TFII-I (8) - sc-136330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TFII-I (8): sc-136330. Western blot analysis of TFII-I expression in HeLa whole cell lysate.

TFII-I (42) - sc-136099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
TFII-I (42): sc-136099. Western blot analysis of TFII-I expression in HeLa whole cell lysate.

Anti-TFII I (phospho Y248) antibody - ab63344 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TFII I (phospho Y248) antibody (ab63344) at 1/500 dilutionLane 1 : extracts from LOVO cells, without immunising peptideLane 2 : extracts from LOVO cells, with immunising peptide

Anti-TFII I antibody - ab88864 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-TFII I antibody (ab88864) at 1 µg/ml + HeLa nuclear extract at 50 µg

Anti-TFII I antibody - ab84412 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast adenocarcinoma, using 1/100 ab84412 followed by DAB staining.

Anti-TFII I antibody - ab10464 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TFII I antibody - ab10465 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling TFII I with ab10465 at 1/5000 (0.2µg/ml). Detection: DAB.

Anti-TFII I antibody - ab55200 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TFII I antibody (ab55200) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-TFII I antibody - ab55201 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TFII I antibody - ab83315 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TFII I antibody (ab83315) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TFII I antibody [EPR7696] - ab134133 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7696
All lanes : Anti-TFII I antibody [EPR7696] (ab134133) at 1/10000 dilutionLane 1 : Human fetal brain lysateLane 2 : Jurkat cell lysateLane 3 : U937 cell lysateLane 4 : HeLa cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-TFII I antibody [EPR7697] - ab129025 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7697
All lanes : Anti-TFII I antibody [EPR7697] (ab129025) at 1/10000 dilutionLane 1 : HeLa cell lysates Lane 2 : 293T cell lysates Lane 3 : U937 cell lysates Lane 4 : Jurkat cell lysates Lysates/proteins at 10 µg per lane.

Anti-TFII I antibody - C-terminal - ab135619 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TFII I antibody - C-terminal (ab135619) at 1/100 dilution + Y79 cells lysate at 35 µg

Anti-GTF2I / TFII I Antibody - LS-C92727 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GTF2I / TFII I Antibody - LS-C92728 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GTF2I / TFII I Antibody (clone 354C4a) - LS-C184813 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 354C4a

Anti-GTF2I / TFII I Antibody (aa208-257) - LS-C31747 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-GTF2I / TFII I Antibody (aa281-310, AP) - LS-C258162 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GTF2I / TFII I Antibody (aa281-310, APC) - LS-C258163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GTF2I / TFII I Antibody (aa281-310, Biotin) - LS-C258164 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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