| Gene Symbol |
GTF2I
|
| Entrez Gene |
2969
|
| Alt Symbol |
BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
general transcription factor IIi
|
| Other Description |
BTK-associated protein, 135kD|Bruton tyrosine kinase-associated protein 135|SRF-Phox1-interacting protein|Williams-Beuren syndrome chromosome region 6|general transcription factor II-I
|
| Swissprots |
Q75M88 Q75M85 Q75M87 Q75M86 O15359 Q9BSZ4 Q86U51 O14743 O43588 O43546 P78347 O43589
|
| Accessions |
AAL93085 AAS07460 AAS07461 AAS07462 AAS07463 AAS07464 EAW69594 EAW69595 EAW69596 EAW69597 EAW69598 P78347 AA641906 AF015553 AAB70791 AF035737 AAC08312 AF038967 AAC08313 AF038968 AAC08314 AF038969 AAC08315 AK057670 AK093663 AK096095 AK292832 BAF85521 AK294935 BAG58013 AK297238 BAG59719 BC004472 AAH04472 BC070484 AAH70484 BC099907 AAH99907 BT007450 AAP36118 CB118501 DC346283 KJ534859 AHW56499 KJ534860 AHW56500 KJ534861 AHW56501 KJ534862 AHW56502 KJ534863 AHW56503 KJ534965 AHW56605 U77948 AAB48826 Y14946 CAA75163 XM_011516110 XP_011514412 XR_927460 NM_001163636 NP_001157108 NM_001280800 NP_001267729 NM_001518 NP_001509 NM_032999 NP_127492 NM_033000 NP_127493 NM_033001 NP_127494
|
| Function |
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.
|
| Tissue Specificity |
Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
|
| Top Pathways |
Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors
|