GTF2I

Gene Symbol	GTF2I
Entrez Gene	2969
Alt Symbol	BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
Species	Human
Gene Type	protein-coding
Description	general transcription factor IIi
Other Description	BTK-associated protein, 135kD|Bruton tyrosine kinase-associated protein 135|SRF-Phox1-interacting protein|Williams-Beuren syndrome chromosome region 6|general transcription factor II-I
Swissprots	Q75M88 Q75M85 Q75M87 Q75M86 O15359 Q9BSZ4 Q86U51 O14743 O43588 O43546 P78347 O43589
Accessions	AAL93085 AAS07460 AAS07461 AAS07462 AAS07463 AAS07464 EAW69594 EAW69595 EAW69596 EAW69597 EAW69598 P78347 AA641906 AF015553 AAB70791 AF035737 AAC08312 AF038967 AAC08313 AF038968 AAC08314 AF038969 AAC08315 AK057670 AK093663 AK096095 AK292832 BAF85521 AK294935 BAG58013 AK297238 BAG59719 BC004472 AAH04472 BC070484 AAH70484 BC099907 AAH99907 BT007450 AAP36118 CB118501 DC346283 KJ534859 AHW56499 KJ534860 AHW56500 KJ534861 AHW56501 KJ534862 AHW56502 KJ534863 AHW56503 KJ534965 AHW56605 U77948 AAB48826 Y14946 CAA75163 XM_011516110 XP_011514412 XR_927460 NM_001163636 NP_001157108 NM_001280800 NP_001267729 NM_001518 NP_001509 NM_032999 NP_127492 NM_033000 NP_127493 NM_033001 NP_127494
Function	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.
Tissue Specificity	Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
Top Pathways	Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TFII-I CRISPR/Cas9 KO Plasmid (h) - sc-403153 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I HDR Plasmid (h) - sc-403153-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I Double Nickase Plasmid (h) - sc-403153-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I Double Nickase Plasmid (h2) - sc-403153-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I CRISPR Activation Plasmid (h) - sc-403153-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I CRISPR Activation Plasmid (h2) - sc-403153-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I Lentiviral Activation Particles (h) - sc-403153-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I Lentiviral Activation Particles (h2) - sc-403153-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TFII-I siRNA (h) - sc-36643 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TFII-I shRNA Plasmid (h) - sc-36643-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TFII-I shRNA (h) Lentiviral Particles - sc-36643-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TFII-I RNAi - H00002969-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TFII-I RNAi - H00002969-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

TFII-I RNAi - H00002969-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU075811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9769 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9769 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

GTF2I siRNA (Human) - CRH2011 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TFII-I RNAi - H00002969-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

GTF2I - MBS8224174 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human GTF2I (NM_001518.3) - SHH308986 from Creative biogene Category siRNA Species Reactivities Human

GTF2I shRNA Plasmid (Human) - CHH2011 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

GTF2I miRNA 3'UTR clone - MiUTR3H-04312 from Creative biogene Species Reactivities Human

GTF2I miRNA 3'UTR clone - MiUTR3H-04313 from Creative biogene Species Reactivities Human

GTF2I miRNA 3'UTR clone - MiUTR3H-04314 from Creative biogene Species Reactivities Human

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