MED15

Gene Symbol	MED15
Entrez Gene	51586
Alt Symbol	ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
Species	Human
Gene Type	protein-coding
Description	mediator complex subunit 15
Other Description	CTG repeat protein 7a|PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein|PC2 glutamine/Q-rich-associated protein|PC2-glutamine-rich-associated protein|TPA inducible gene-1|TPA inducible protein|TPA-inducible gene 1 protein|activator-recruited cofactor 105 kDa component|activator-recruited cofactor, 105-kD|mediator of RNA polymerase II transcription subunit 15|positive cofactor 2 glutamine/Q-rich-associated protein|positive cofactor 2, glutamine/Q-rich-associated protein|trinucleotide repeat containing 7|trinucleotide repeat-containing gene 7 protein
Swissprots	Q96IH7 O15413 Q96RN5 Q6IC31 D3DX31 Q9P1T3 D3DX32 Q8NF16 Q96CT0
Accessions	EAX02948 EAX02949 EAX02950 EAX02951 EAX02952 EAX02953 EAX02954 EAX02955 EAX02956 Q96RN5 AF056191 AAC12944 AF328769 AAK58423 AK000003 BAA92228 AK074230 AK074268 BAB85034 AK090465 BAC03446 AK124276 BAG54024 AK124925 BAG54113 AK126208 AK294540 BAG57747 AK294734 BAH11863 AK297284 BAG59755 AK297789 BAG60130 AK315540 AL832151 CAH10580 AL832923 CAH10623 AW245653 BC003078 AAH03078 BC005027 BC007529 AAH07529 BC013985 AAH13985 BC017110 BX478424 CB156495 CB988805 CR456537 CAG30423 CU013137 CAK54568 CU013425 CAK54867 DA182752 KF274544 KF274593 U80745 AAB91443 XM_006724263 XP_006724326 XM_006724264 XP_006724327 XM_011530214 XP_011528516 XM_011530215 XP_011528517 XM_011530216 XP_011528518 XM_011530217 XP_011528519 XM_011530218 XP_011528520 XM_011530219 XP_011528521 XM_011530220 XP_011528522 XM_011530221 XP_011528523 NM_001003891 NP_001003891 NM_001293234 NP_001280163 NM_001293235 NP_001280164 NM_001293236 NP_001280165 NM_001293237 NP_001280166 NM_015889 NP_056973
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney. {ECO:0000269|PubMed:11024300}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PCQAP / MED15 full length protein - ab162600 from Abcam Category Protein Source Wheat germ Species Human

Human PCQAP / MED15 protein fragment - ab162601 from Abcam Category Protein Source Wheat germ Species Human

MED15 / ARC105 Antibody Blocking Peptide - LS-E26984 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MED15 Protein - H00051586-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MED15 Partial Recombinant Protein - H00051586-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MED15 peptide - orb218538 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

MED15 Blocking Peptide - abx063869 from Abbexa Category Peptide Species Human, Mouse, Rat, Zebrafish

PCQAP / MED15 Peptide - AC21-1809-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MED15 - H00051586-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MED15 - H00051586-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MED15 - H00051586-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MED15 Peptide - 46-928P from ProSci Category Peptide Species Human

MED15 fusion protein - ag2143 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MED15 fusion protein - ag13344 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MED15 fusion protein - ag13377 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MED15 Blocking Peptide - CBP2675 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

Recombinant Human Mediator of RNA polymerase II transcription subunit 15(MED15) - CSB-YP842753HU CSB-EP842753HU CSB-BP842753HU CSB-MP842753HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MED15 (transcript variant 2) - TP304224 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PCQAP/MED15 , Peptide - MBS425690 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

MED15 Recombinant Protein Antigen - NBP1-89018PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PCQAP-Antibody-Center-Blocking-Peptide - BP9457c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MED15 Peptide, Human - M34GP09360H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mediator of RNA polymerase II transcription subunit 15 (MED15), Recombinant Protein - MBS1338914 from MyBioSource Category Protein Prices $1,605.00, $1,605.00, $1,835.00, $1,835.00, $2,760.00, $2,760.00, $3,225.00, $3,225.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MED15 Immunizing peptide - orb17228 from Biorbyt Category Peptide

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