ADAR

Gene Symbol ADAR
Entrez Gene 103
Alt Symbol ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136
Species Human
Gene Type protein-coding
Description adenosine deaminase, RNA-specific
Other Description 136 kDa double-stranded RNA-binding protein|RNA-specific adenosine deaminase|adenosine deaminase acting on RNA 1-A|double-stranded RNA-specific adenosine deaminase|dsRNA adenosine deaminase|interferon-induced protein 4|interferon-inducible protein 4
Swissprots D3DV76 Q9BYM3 P55265 O43859 O43860 B1AQR0 O15223 Q9BYM4 B1AQQ9
Accessions AAB97116 AAB97117 AAB97118 CAA67172 EAW53183 EAW53184 EAW53185 EAW53186 EAW53187 EAW53188 EAW53189 EAW53190 P55265 AA449679 AB209891 BAD93128 AF084516 AK097241 AK304153 BAH14119 BC017853 BC038227 AAH38227 BE886208 BU430287 BX538232 CAD98075 BX640741 CAE45853 CD108625 CR982397 DA507408 DR158819 EF190448 ABM73519 EF190449 ABM73520 EF190450 EF190451 EF190452 EF190453 EU176459 ABW03910 EU176799 ABW03600 KJ544856 AHZ44503 U10439 AAB06697 U18121 AAC13782 X79448 CAA55967 X79449 CAA55968 X98559 CAA67169 X98561 X98563 XM_006711109 XP_006711172 XM_006711111 XP_006711174 XM_006711112 XP_006711175 XM_006711113 XP_006711176 XM_011509060 XP_011507362 XM_011509061 XP_011507363 XM_011509062 XP_011507364 NM_001025107 NP_001020278 NM_001111 NP_001102 NM_001193495 NP_001180424 NM_015840 NP_056655 NM_015841 NP_056656
Function Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer- associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding
Subcellular Location Isoform 1: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
Tissue Specificity Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. {ECO:0000269|PubMed:18178553}.
Top Pathways Cytosolic DNA-sensing pathway, Measles, Influenza A

ADAR1 (D7E2M) Rabbit mAb - 14175 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7E2M
Western blot analysis of extracts from HeLa cells, untreated (-) or treated with hIFN-α1 #8927 (+), and Hep G2 and Vero cells, using ADAR1 (D7E2M) Rabbit mAb.

ADAR1 Antibody - 12317 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

ADAR1 (15.8.6) - sc-73408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR1 (15.8.6): sc-73408. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear staining of cells in seminiferous ducts.

ADAR1 (C-16) - sc-10002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAR1 (C-16): sc-10002. Western blot analysis of ADAR1 expression in Ramos nuclear extract.

ADAR1 (D-8) - sc-271854 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAR1 (D-8): sc-271854. Western blot analysis of ADAR1 expression in NTERA-cl.D1 (A), U-2 OS (B) and Ramos (C) whole cell lysates and HeLa (D) and K-562 (E) nuclear extracts.

ADAR1 (L-15) - sc-19077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAR1 (L-15): sc-19077. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing nuclear and cytoplasmic staining of neuronal cells and nuclear staining of glial cells.

ADAR1 (H-176) - sc-33179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-ADAR1 antibody - ab88574 from Abcam

Prices $390.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ADAR1 antibody (ab88574) at 1 µg/ml + Human liver lysate at 50 µg

Anti-ADAR1 antibody - ab168809 from Abcam

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAR1 antibody (ab168809) at 0.4 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-ADAR1 antibody - ab97640 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAR1 antibody (ab97640) at 1/1000 dilution + NIH 3T3 whole cell lysate at 30 µg

Anti-ADAR1 antibody - ab111307 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human brain tissue, using ab111307 at a dilution of 1/50. Left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide.

Anti-ADAR1 antibody - ab65226 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ADAR1 antibody (ab65226) at 1/60 dilution + NCI-H460 cell line lysates at 35 µg

Anti-ADAR1 antibody - ab16138 from Abcam

Prices $370.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-ADAR1 antibody [EPR7033] - ab126745 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7033
All lanes : Anti-ADAR1 antibody [EPR7033] (ab126745) at 1/1000 dilutionLane 1 : HeLa (treated with IFN-alpha) cell lysateLane 2 : HeLa cell lysateLane 3 : Ramos cell lysateLane 4 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ADAR1 antibody [EPR7034] - ab126755 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7034
All lanes : Anti-ADAR1 antibody [EPR7034] (ab126755) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution

Anti-ADAR1 antibody [GT1066] - ab184527 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT1066
All lanes : Anti-ADAR1 antibody [GT1066] (ab184527) at 1/1000 dilutionLane 1 : HEK293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : HepG2 whole cell lysateLane 5 : A375 whole cell lysateLysates/proteins at 30 µg per lane.

ADAR1 Polyclonal Antibody - bs-2167R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human cervical cancer labeled with Anti-ADAR1 (N-terminus) Polyclonal Antibody, Unconjugated(bs-2167R) followed by conjugation to the secondary antibody and DAB staining

ADAR1 Polyclonal Antibody - bs-2168R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-ADAR1 antibody produced in mouse - SAB4200482 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone ADAR61
<B>Immunoblotting</B><BR/>Whole extract of U-2-OS cells was separated on SDS-PAGE and probed with Mouse Anti-ADAR1 Clone: ADAR61 (<B>Cat. No. SAB4200482</B>). The antibody was developed using Goat Anti-Mouse IgG-Peroxidase (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. 4 μg/mL antibody<BR/>2. 4 μg/mL antibody + 90 μg/mL ADAR1 immunizing peptide (human, 483-499)<BR/>3. 4 μg/mL antibody + 90 μg/mL ADAR1 immunizing peptide (human, 1075-1094)

Anti-ADAR1, C-Terminal antibody produced in rabbit - SAB4500077 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ADAR1, C-Terminal: <B>Cat. No. SAB4500077</B>: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-ADAR1, C-Terminal antibody. Cells on the left were treated with the Anti-ADAR1, C-Terminal antibody. Cells on the right (negative control) were treated with both Anti-ADAR1, C-Terminal antibody and the synthesized immunogen peptide.

Anti-ADAR1 (C-terminal) antibody produced in rabbit - SAB4200542 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoprecipitation</B><BR/>Rabbit Anti-ADAR1 (C-terminal) (<B>Cat. No. SAB4200542</B>) was used to immunoprecipitate ADAR1 from HepG2 (lanes 1-4) and HEK-293T (lanes 5-8) whole cell extracts. Detection antibody: Rabbit Anti-ADAR1 (<B>Cat. No. SAB4200541</B>).<BR/><B>Lanes</B><BR/>1 and 5. Positive control: whole cell extract<BR/>2 and 6. 20 μg antibody<BR/>3 and 7. 10 μg antibody<BR/>4 and 8. Negative control: 10 μg non-relevant antibody

Monoclonal Anti-ADAR antibody produced in mouse - AMAB90535 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CL0176
<B>Immunohistochemistry</B><BR/>Anti-ADAR: <B>Cat. No. AMAB90535</B>: Immunohistochemical staining of human cerebral cortex shows nuclear positivity.

Anti-ADAR antibody produced in mouse - SAB1405425 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ADAR: <B>Cat. No. SAB1405425</B>: Antibody concentration: 3 μg/mL using human lung tissue.

Anti-ADAR antibody produced in rabbit - SAB1401004 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-ADAR, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401004</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Specific band of ~135.97 kDa using HeLa lysate.

ADAR antibody - C-terminal region (ARP36712_P050) - ARP36712_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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