| Gene Symbol |
RNASE7
|
| Entrez Gene |
84659
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease, RNase A family, 7
|
| Other Description |
RNase 7|SAP-2|ribonuclease 7|skin-derived antimicrobial protein 2
|
| Swissprots |
Q546N3 Q9H1E1 P80927 P83685
|
| Accessions |
EAW66418 EAW66419 Q9H1E1 AI150610 AJ131212 CAC20410 AJ306608 CAC84462 AJ306609 CAC84457 AJ306610 CAC84458 AK292697 BAF85386 AY170392 AAO12510 AY359097 AAQ89455 BC074960 AAH74960 BC112334 AAI12335 DB153740 NM_032572 NP_115961
|
| Function |
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768}.
|
![Western Blot: RNASE7 Overexpression Lysate (Adult Normal) [NBP2-05996] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNASE7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1919_RNASE7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05996-img0001.jpg)