Gene Symbol | RNASE7 |
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Entrez Gene | 84659 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease, RNase A family, 7 |
Other Description | RNase 7|SAP-2|ribonuclease 7|skin-derived antimicrobial protein 2 |
Swissprots | Q546N3 Q9H1E1 P80927 P83685 |
Accessions | EAW66418 EAW66419 Q9H1E1 AI150610 AJ131212 CAC20410 AJ306608 CAC84462 AJ306609 CAC84457 AJ306610 CAC84458 AK292697 BAF85386 AY170392 AAO12510 AY359097 AAQ89455 BC074960 AAH74960 BC112334 AAI12335 DB153740 NM_032572 NP_115961 |
Function | Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768}. |
RNase 7 CRISPR/Cas9 KO Plasmid (h) - sc-416419 from Santa Cruz Biotechnology
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RNase 7 HDR Plasmid (h) - sc-416419-HDR from Santa Cruz Biotechnology
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RNase 7 Double Nickase Plasmid (h) - sc-416419-NIC from Santa Cruz Biotechnology
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RNase 7 Double Nickase Plasmid (h2) - sc-416419-NIC-2 from Santa Cruz Biotechnology
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RNase 7 CRISPR Activation Plasmid (h) - sc-416419-ACT from Santa Cruz Biotechnology
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RNase 7 CRISPR Activation Plasmid (h2) - sc-416419-ACT-2 from Santa Cruz Biotechnology
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RNase 7 Lentiviral Activation Particles (h) - sc-416419-LAC from Santa Cruz Biotechnology
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RNase 7 Lentiviral Activation Particles (h2) - sc-416419-LAC-2 from Santa Cruz Biotechnology
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RNase 7 siRNA (h) - sc-92112 from Santa Cruz Biotechnology
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RNase 7 shRNA Plasmid (h) - sc-92112-SH from Santa Cruz Biotechnology
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RNase 7 shRNA (h) Lentiviral Particles - sc-92112-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU003401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18349 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18349 from Sigma-Aldrich
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RNASE7 siRNA (Human) - CRJ3562 from Cohesion Biosciences
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RNASE7 RNAi - H00084659-R01 from Novus Biologicals
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RNASE7 - MBS8226159 from MyBioSource
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shRNA set against Human RNASE7 (NM_032572.3) - SHH396340 from Creative biogene
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RNASE7 shRNA Plasmid (Human) - CHJ3562 from Cohesion Biosciences
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RNASE7 miRNA 3'UTR clone - MiUTR1H-08858 from Creative biogene
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