| Gene Symbol |
ARHGAP24
|
| Entrez Gene |
83478
|
| Alt Symbol |
FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GTPase activating protein 24
|
| Other Description |
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa|filamin-A-associated RhoGAP|rho GTPase-activating protein 24|rho-type GTPase-activating protein 24|rhoGAP of 73 kDa|sarcoma antigen NY-SAR-88
|
| Swissprots |
Q8N264 Q86WE4 Q6ZNV3 Q86TI5 Q4KMG1 Q9H0T6
|
| Accessions |
EAX05959 EAX05960 EAX05961 Q8N264 AK091196 BAC03606 AK098193 BAG53589 AK130576 BAC85384 AK307423 AK308019 AL136646 CAB66581 AY211925 AAO65178 BC047918 AAH47918 BC098580 AAH98580 DA546029 DA815489 DB109452 XM_005263263 XP_005263320 XM_011532300 XP_011530602 NM_001025616 NP_001020787 NM_001042669 NP_001036134 NM_001287805 NP_001274734 NM_031305 NP_112595
|
| Function |
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
|
| Tissue Specificity |
Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
|