ARHGAP24

Gene Symbol ARHGAP24
Entrez Gene 83478
Alt Symbol FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP
Species Human
Gene Type protein-coding
Description Rho GTPase activating protein 24
Other Description RAC1- and CDC42-specific GTPase-activating protein of 72 kDa|filamin-A-associated RhoGAP|rho GTPase-activating protein 24|rho-type GTPase-activating protein 24|rhoGAP of 73 kDa|sarcoma antigen NY-SAR-88
Swissprots Q8N264 Q86WE4 Q6ZNV3 Q86TI5 Q4KMG1 Q9H0T6
Accessions EAX05959 EAX05960 EAX05961 Q8N264 AK091196 BAC03606 AK098193 BAG53589 AK130576 BAC85384 AK307423 AK308019 AL136646 CAB66581 AY211925 AAO65178 BC047918 AAH47918 BC098580 AAH98580 DA546029 DA815489 DB109452 XM_005263263 XP_005263320 XM_011532300 XP_011530602 NM_001025616 NP_001020787 NM_001042669 NP_001036134 NM_001287805 NP_001274734 NM_031305 NP_112595
Function Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
Subcellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
Tissue Specificity Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.

Human Rho GTPase-activating protein 24 full length protein - ab164402 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164402 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ARHGAP24 Antibody Blocking Peptide - LS-E2739 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human ARHGAP24 Protein - H00083478-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

ARHGAP24-Antibody-C-term-Blocking-peptide - BP13826b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ARHGAP24 / FILGAP - H00083478-P01 from Acris Antibodies

Category Protein
Prices $340.00
Sizes 2 µg
Species Human

Recombinant Human Rho GTPase-activating protein 24(ARHGAP24) - CSB-YP836648HU CSB-EP836648HU CSB-BP836648HU CSB-MP836648HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

ARHGAP24 / FILGAP (transcript variant 1) - TP311832 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
ARHGAP24 / FILGAP

ARHGAP24 Recombinant Protein Antigen - NBP1-84161PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ARHGAP24 Peptide, Human - M34GP00854H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Rho GTPase-activating protein 24 (ARHGAP24), Recombinant Protein - MBS1374414 from MyBioSource

Category Protein
Prices $1,560.00, $1,560.00, $1,790.00, $1,790.00, $2,690.00, $2,690.00, $3,130.00, $3,130.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
Search more