ARHGAP24

Gene Symbol ARHGAP24
Entrez Gene 83478
Alt Symbol FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP
Species Human
Gene Type protein-coding
Description Rho GTPase activating protein 24
Other Description RAC1- and CDC42-specific GTPase-activating protein of 72 kDa|filamin-A-associated RhoGAP|rho GTPase-activating protein 24|rho-type GTPase-activating protein 24|rhoGAP of 73 kDa|sarcoma antigen NY-SAR-88
Swissprots Q8N264 Q86WE4 Q6ZNV3 Q86TI5 Q4KMG1 Q9H0T6
Accessions EAX05959 EAX05960 EAX05961 Q8N264 AK091196 BAC03606 AK098193 BAG53589 AK130576 BAC85384 AK307423 AK308019 AL136646 CAB66581 AY211925 AAO65178 BC047918 AAH47918 BC098580 AAH98580 DA546029 DA815489 DB109452 XM_005263263 XP_005263320 XM_011532300 XP_011530602 NM_001025616 NP_001020787 NM_001042669 NP_001036134 NM_001287805 NP_001274734 NM_031305 NP_112595
Function Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
Subcellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
Tissue Specificity Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.

ARHGAP24 CRISPR/Cas9 KO Plasmid (h) - sc-413476 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 HDR Plasmid (h) - sc-413476-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 Double Nickase Plasmid (h) - sc-413476-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 Double Nickase Plasmid (h2) - sc-413476-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 CRISPR Activation Plasmid (h) - sc-413476-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 CRISPR Activation Plasmid (h2) - sc-413476-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 Lentiviral Activation Particles (h) - sc-413476-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 Lentiviral Activation Particles (h2) - sc-413476-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARHGAP24 siRNA (h) - sc-88894 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARHGAP24 shRNA Plasmid (h) - sc-88894-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARHGAP24 shRNA (h) Lentiviral Particles - sc-88894-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU073311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3418 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3418 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ARHGAP24 siRNA (Human) - CRJ3114 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARHGAP24 - MBS8211444 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARHGAP24 (NM_031305.2) - SHH239418 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARHGAP24(NM_001042669.1) - SHG069645 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARHGAP24(NM_031305.2) - SHG069703 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ARHGAP24(NM_001025616.2) - SHG069721 from Creative biogene

Category siRNA
Species Reactivities Human

Human ARHGAP24 siRNA - orb273615 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARHGAP24 shRNA Plasmid (Human) - CHJ3114 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARHGAP24 miRNA 3'UTR clone - MiUTR1H-00518 from Creative biogene

Species Reactivities Human

ARHGAP24 miRNA 3'UTR clone - MiUTR1H-00519 from Creative biogene

Species Reactivities Human

ARHGAP24 miRNA 3'UTR clone - MiUTR1H-00520 from Creative biogene

Species Reactivities Human
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