| Gene Symbol | ASPA |
|---|---|
| Entrez Gene | 443 |
| Alt Symbol | ACY2, ASP |
| Species | Human |
| Gene Type | protein-coding |
| Description | aspartoacylase |
| Other Description | ACY-2|aminoacylase 2|aminoacylase-2 |
| Swissprots | P45381 |
| Accessions | AAD14981 EAW90506 EAW90507 P45381 AK312901 BAG35747 BC010941 BC029128 AAH29128 CR541908 CAG46706 DQ892079 ABM83005 DQ895272 ABM86198 S67156 AAB29190 XM_006721527 XP_006721590 XR_934026 NM_000049 NP_000040 NM_001128085 NP_001121557 |
| Function | Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250}. |
| Tissue Specificity | Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver. |
| Top Pathways | Alanine, aspartate and glutamate metabolism, Histidine metabolism |