Gene Symbol | ASPA |
---|---|
Entrez Gene | 443 |
Alt Symbol | ACY2, ASP |
Species | Human |
Gene Type | protein-coding |
Description | aspartoacylase |
Other Description | ACY-2|aminoacylase 2|aminoacylase-2 |
Swissprots | P45381 |
Accessions | AAD14981 EAW90506 EAW90507 P45381 AK312901 BAG35747 BC010941 BC029128 AAH29128 CR541908 CAG46706 DQ892079 ABM83005 DQ895272 ABM86198 S67156 AAB29190 XM_006721527 XP_006721590 XR_934026 NM_000049 NP_000040 NM_001128085 NP_001121557 |
Function | Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. |
Subcellular Location | Cytoplasm. Nucleus {ECO:0000250}. |
Tissue Specificity | Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver. |
Top Pathways | Alanine, aspartate and glutamate metabolism, Histidine metabolism |
Aspartoacylase CRISPR/Cas9 KO Plasmid (h) - sc-405771 from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase HDR Plasmid (h) - sc-405771-HDR from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase Double Nickase Plasmid (h) - sc-405771-NIC from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase Double Nickase Plasmid (h2) - sc-405771-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase CRISPR Activation Plasmid (h) - sc-405771-ACT from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase CRISPR Activation Plasmid (h2) - sc-405771-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase Lentiviral Activation Particles (h) - sc-405771-LAC from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase Lentiviral Activation Particles (h2) - sc-405771-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase siRNA (h) - sc-93596 from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase shRNA Plasmid (h) - sc-93596-SH from Santa Cruz Biotechnology
|
||||||||
Aspartoacylase shRNA (h) Lentiviral Particles - sc-93596-V from Santa Cruz Biotechnology
|
||||||||
ASPA RNAi - H00000443-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU143401 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3603 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3603 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02370 from Sigma-Aldrich
|
||||||||
ASPA siRNA (Human) - CRH0318 from Cohesion Biosciences
|
||||||||
ASPA - MBS8225189 from MyBioSource
|
||||||||
shRNA set against Human ASPA (NM_000049.2) - SHH241574 from Creative biogene
|
||||||||
shRNA set against Human ASPA(NM_000049.2) - SHG077911 from Creative biogene
|
||||||||
ASPA shRNA Plasmid (Human) - CHH0318 from Cohesion Biosciences
|
||||||||
ASPA miRNA 3'UTR clone - MiUTR1H-00641 from Creative biogene
|
||||||||
ASPA miRNA 3'UTR clone - MiUTR3H-09680 from Creative biogene
|