Gene Symbol | GRPEL2 |
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Entrez Gene | 134266 |
Alt Symbol | Mt-GrpE#2 |
Species | Human |
Gene Type | protein-coding |
Description | GrpE-like 2, mitochondrial (E. coli) |
Other Description | grpE protein homolog 2, mitochondrial |
Swissprots | Q8TAA5 B4DFA6 Q49AJ6 |
Accessions | EAW61786 Q8TAA5 AK074293 BAB85040 AK091237 AK096445 AK294005 BAG57367 AL704536 AL832325 CAD38619 BC036678 AAH36678 BC070090 AAH70090 HQ447481 ADQ31967 NM_152407 NP_689620 |
Function | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion matrix {ECO:0000250}. |
GrpEL2 CRISPR/Cas9 KO Plasmid (h) - sc-408498 from Santa Cruz Biotechnology
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GrpEL2 HDR Plasmid (h) - sc-408498-HDR from Santa Cruz Biotechnology
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GrpEL2 Double Nickase Plasmid (h) - sc-408498-NIC from Santa Cruz Biotechnology
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GrpEL2 Double Nickase Plasmid (h2) - sc-408498-NIC-2 from Santa Cruz Biotechnology
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GrpEL2 CRISPR Activation Plasmid (h) - sc-408498-ACT from Santa Cruz Biotechnology
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GrpEL2 CRISPR Activation Plasmid (h2) - sc-408498-ACT-2 from Santa Cruz Biotechnology
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GrpEL2 Lentiviral Activation Particles (h) - sc-408498-LAC from Santa Cruz Biotechnology
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GrpEL2 Lentiviral Activation Particles (h2) - sc-408498-LAC-2 from Santa Cruz Biotechnology
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GrpEL2 siRNA (h) - sc-91628 from Santa Cruz Biotechnology
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GrpEL2 shRNA Plasmid (h) - sc-91628-SH from Santa Cruz Biotechnology
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GrpEL2 shRNA (h) Lentiviral Particles - sc-91628-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU065941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9710 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9710 from Sigma-Aldrich
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GRPEL2 siRNA (Human) - CRJ5137 from Cohesion Biosciences
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GRPEL2 - MBS8220219 from MyBioSource
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shRNA set against Human GRPEL2 (NM_152407.3) - SHH308226 from Creative biogene
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Human GRPEL2 siRNA - orb275638 from Biorbyt
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GRPEL2 shRNA Plasmid (Human) - CHJ5137 from Cohesion Biosciences
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GRPEL2 miRNA 3'UTR clone - MiUTR1H-04297 from Creative biogene
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