| Gene Symbol |
GCNT4
|
| Entrez Gene |
51301
|
| Alt Symbol |
C2GNT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucosaminyl (N-acetyl) transferase 4, core 2
|
| Other Description |
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4|core 2 beta-1,6-N-acetylglucosaminyltransferase 3|core 2-branching enzyme 3|core2-GlcNAc-transferase 3|glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
|
| Swissprots |
Q9P109
|
| Accessions |
CAC34674 CAD35101 EAW95751 Q9P109 AF132035 AAF63156 BC160070 AAI60070 NM_016591 NP_057675
|
| Function |
Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. {ECO:0000269|PubMed:10753916}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in thymus. Weakly expressed in pancreas, peripheral blood leukocytes, placenta, small intestine and stomach. Barely detectable in liver, spleen, lung and lymph node. {ECO:0000269|PubMed:10753916}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|