| Gene Symbol | AKT3 |
|---|---|
| Entrez Gene | 10000 |
| Alt Symbol | MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-akt murine thymoma viral oncogene homolog 3 |
| Other Description | PKB gamma|RAC-gamma serine/threonine protein kinase|RAC-gamma serine/threonine-protein kinase|v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) |
| Swissprots | Q96QV3 Q5VTI1 Q5VTI2 Q9UFP5 Q9Y243 Q0VAA6 |
| Accessions | CAC22382 CAC93797 EAW77093 EAW77094 Q9Y243 AF085234 AAL40392 AF124141 AAD29089 AF135794 AAD24196 AJ245709 CAB53537 AK055109 AK308052 AL117525 CAB55977 AM392791 CAL37669 AM392849 CAL37727 AW960221 AY005799 AAF91073 BC019085 BC020479 AAH20479 BC121154 AAI21155 BG702262 U79271 XM_005272994 XP_005273051 XM_005272995 XP_005273052 XM_005272997 XP_005273054 XM_006711726 XP_006711789 XM_006724959 XP_006725022 XM_006724960 XP_006725023 XM_006724962 XP_006725025 XM_006724963 XP_006725026 XM_011544011 XP_011542313 XM_011544012 XP_011542314 XM_011544013 XP_011542315 XM_011544014 XP_011542316 XM_011546424 XP_011544726 XM_011546425 XP_011544727 XM_011546426 XP_011544728 XM_011546427 XP_011544729 NM_001206729 NP_001193658 NM_005465 NP_005456 NM_181690 NP_859029 |
| Function | AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. {ECO:0000269|PubMed:18524868, EC |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:20018949}. Cytoplasm {ECO:0000269|PubMed:20018949}. Membrane {ECO:0000269|PubMed:20018949}; Peripheral membrane protein {ECO:0000269|PubMed:20018949}. Note=Membrane-associated after cell stimulation leading to its translocation. |
| Tissue Specificity | In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. |
| Top Pathways | Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway |