AKT3

Gene Symbol	AKT3
Entrez Gene	10000
Alt Symbol	MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Species	Human
Gene Type	protein-coding
Description	v-akt murine thymoma viral oncogene homolog 3
Other Description	PKB gamma|RAC-gamma serine/threonine protein kinase|RAC-gamma serine/threonine-protein kinase|v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Swissprots	Q96QV3 Q5VTI1 Q5VTI2 Q9UFP5 Q9Y243 Q0VAA6
Accessions	CAC22382 CAC93797 EAW77093 EAW77094 Q9Y243 AF085234 AAL40392 AF124141 AAD29089 AF135794 AAD24196 AJ245709 CAB53537 AK055109 AK308052 AL117525 CAB55977 AM392791 CAL37669 AM392849 CAL37727 AW960221 AY005799 AAF91073 BC019085 BC020479 AAH20479 BC121154 AAI21155 BG702262 U79271 XM_005272994 XP_005273051 XM_005272995 XP_005273052 XM_005272997 XP_005273054 XM_006711726 XP_006711789 XM_006724959 XP_006725022 XM_006724960 XP_006725023 XM_006724962 XP_006725025 XM_006724963 XP_006725026 XM_011544011 XP_011542313 XM_011544012 XP_011542314 XM_011544013 XP_011542315 XM_011544014 XP_011542316 XM_011546424 XP_011544726 XM_011546425 XP_011544727 XM_011546426 XP_011544728 XM_011546427 XP_011544729 NM_001206729 NP_001193658 NM_005465 NP_005456 NM_181690 NP_859029
Function	AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. {ECO:0000269|PubMed:18524868, EC
Subcellular Location	Nucleus {ECO:0000269|PubMed:20018949}. Cytoplasm {ECO:0000269|PubMed:20018949}. Membrane {ECO:0000269|PubMed:20018949}; Peripheral membrane protein {ECO:0000269|PubMed:20018949}. Note=Membrane-associated after cell stimulation leading to its translocation.
Tissue Specificity	In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
Top Pathways	Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AKT3 (mutated E17 K) full length protein - ab186457 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human AKT3 (mutated G171 R) full length protein - ab177263 from Abcam Category Protein Prices $361.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human AKT3 full length protein - ab168019 from Abcam Category Protein Prices $341.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human AKT3 full length protein - ab79799 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human AKT3 full length protein - ab60324 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human AKT3 full length protein - ab160754 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AKT3 full length protein - ab43621 from Abcam Category Protein Prices $388.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human AKT3 peptide - ab89371 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human AKT3 protein fragment - ab160755 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AKT3 Antibody Blocking Peptide - LS-E25796 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKT3 Antibody Blocking Peptide - LS-E7391 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKT3 Antibody Blocking Peptide - LS-E8624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKT3 Antibody Blocking Peptide - LS-E8623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Akt3 Recombinant Protein - H00010000-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Akt3 Partial Recombinant Protein - H00010000-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Akt3 Recombinant Protein - P4187 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Akt3 Recombinant Protein - P4648 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Akt3 Peptide - P1602 from Novus Biologicals Category Peptide Species Human

Akt3 Peptide - P2120 from Novus Biologicals Category Peptide Species Human

Akt3 Peptide - P2119 from Novus Biologicals Category Peptide Species Human

AKT3-Antibody-C-term-Blocking-Peptide - BP7030b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-AKT3S472-Antibody-Blocking-peptide - BP3468a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

AKT3-Antibody-T447-Blocking-Peptide - BP7030e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKT3-Antibody-S472-Blocking-Peptide - BP7030d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKT3-Antibody-Center-Blocking-Peptide - BP7030c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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