Gene Symbol | CHL1 |
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Entrez Gene | 10752 |
Alt Symbol | CALL, L1CAM2 |
Species | Human |
Gene Type | protein-coding |
Description | cell adhesion molecule L1-like |
Other Description | L1 cell adhesion molecule 2|cell adhesion molecule with homology to L1CAM (close homolog of L1)|cell adhesion molecule with homology to L1CAM (close homologue of L1)|close homolog of L1|neural cell adhesion molecule L1-like protein |
Swissprots | B7ZL03 O00533 Q59FY0 Q2M3G2 |
Accessions | EAW63868 EAW63869 O00533 AB209329 BAD92566 AF002246 AAB60937 AK055236 AK126878 BAG54387 AL359583 BC104918 AAI04919 BC143496 AAI43497 BC143498 BF056756 CR749682 DA778898 R40400 XM_006712938 XP_006713001 XM_006712939 XP_006713002 XM_006712940 XP_006713003 XM_011533292 XP_011531594 XM_011533293 XP_011531595 XM_011533294 XP_011531596 XM_011533295 XP_011531597 XM_011533296 XP_011531598 XM_011533297 XP_011531599 NM_001253387 NP_001240316 NM_001253388 NP_001240317 NM_006614 NP_006605 NR_045572 |
Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}. |
Tissue Specificity | Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. {ECO:0000269|PubMed:9799093}. |
CHL1 (N-14) - sc-34988 from Santa Cruz Biotechnology
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CHL1 (N-18) - sc-34989 from Santa Cruz Biotechnology
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CHL1 (C-18) - sc-34986 from Santa Cruz Biotechnology
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CHL1 (H-88) - sc-98790 from Santa Cruz Biotechnology
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Anti-CHL1 antibody - ab106269 from Abcam
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Anti-CHL1 antibody - ab194437 from Abcam
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Anti-CHL1 Antibody (aa25-1096, Biotin) - LS-C346413 from LifeSpan Bioscience
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CHL-1/L1CAM-2 Antibody (316223) - MAB2126 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - AF2126 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - NBP2-15885 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - NBP1-32960 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - 35790002 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - H00010752-A01 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody - NBP1-86660 from Novus Biologicals
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CHL-1/L1CAM-2 Antibody [Biotin] - BAF2126 from Novus Biologicals
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Rabbit Anti-CHL1/CALL Polyclonal Antibody - bs-11046R from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11046R-A350 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11046R-A488 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11046R-A555 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11046R-A647 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, Cy3 Conjugated - bs-11046R-Cy3 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, Cy5 Conjugated - bs-11046R-Cy5 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, Cy5.5 Conjugated - bs-11046R-Cy5.5 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, Cy7 Conjugated - bs-11046R-Cy7 from Bioss
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Rabbit Anti-CHL1/CALL Polyclonal Antibody, FITC Conjugated - bs-11046R-FITC from Bioss
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