Gene Symbol | CHL1 |
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Entrez Gene | 10752 |
Alt Symbol | CALL, L1CAM2 |
Species | Human |
Gene Type | protein-coding |
Description | cell adhesion molecule L1-like |
Other Description | L1 cell adhesion molecule 2|cell adhesion molecule with homology to L1CAM (close homolog of L1)|cell adhesion molecule with homology to L1CAM (close homologue of L1)|close homolog of L1|neural cell adhesion molecule L1-like protein |
Swissprots | B7ZL03 O00533 Q59FY0 Q2M3G2 |
Accessions | EAW63868 EAW63869 O00533 AB209329 BAD92566 AF002246 AAB60937 AK055236 AK126878 BAG54387 AL359583 BC104918 AAI04919 BC143496 AAI43497 BC143498 BF056756 CR749682 DA778898 R40400 XM_006712938 XP_006713001 XM_006712939 XP_006713002 XM_006712940 XP_006713003 XM_011533292 XP_011531594 XM_011533293 XP_011531595 XM_011533294 XP_011531596 XM_011533295 XP_011531597 XM_011533296 XP_011531598 XM_011533297 XP_011531599 NM_001253387 NP_001240316 NM_001253388 NP_001240317 NM_006614 NP_006605 NR_045572 |
Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}. |
Tissue Specificity | Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. {ECO:0000269|PubMed:9799093}. |
Human CHL1 peptide - ab104388 from Abcam
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Human CHL1 protein fragment - ab127358 from Abcam
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CHL-1/L1CAM-2 Partial Recombinant Protein - H00010752-Q01 from Novus Biologicals
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CHL1-Antibody-Center-Blocking-Peptide - BP8662c from Abgent, a WuXi AppTec company
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Recombinant Human CHL-1/L1CAM-2, CF - 2126-CH-025 from R&D Systems
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Human CALL protein - orb83946 from Biorbyt
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CHL1 - H00010752-Q01-10 from Acris Antibodies
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CHL1 - H00010752-Q01-25 from Acris Antibodies
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CHL1 fusion protein - ag19218 from Proteintech Group
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CHL1 fusion protein - Ag19263 from Proteintech Group
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Recombinant Human CHL1, His tagged - CHL1-3145H from Creative Biomart
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CHL1 - PN201302 from Elabscience
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Recombinant Cell Adhesion Molecule With Homology To L1CAM (CHL1) - RPQ118Hu01 from Uscn Life Science Inc.
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Human CHL-1 Protein (His Tag) - 10143-H08H-20 from Sino Biological
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Recombinant Cell Adhesion Molecule With Homology To L1CAM (CHL1) - RPQ118Hu01 from Cloud-clone
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Recombinant Human CHL-1/L1CAM-2 Protein, CF - 2126-CH from R&D Systems
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Cell Adhesion Molecule With Homology To L1CAM, Recombinant Protein - MBS2029253 from MyBioSource
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Recombinant Human CHL-1 Protein (His tag) - PKSH031836 from Elabscience
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CHL-1/L1CAM-2 Recombinant Protein Antigen - NBP1-86660PEP from Novus Biologicals
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CHL1 Peptide, Human - M34GP03097H from Creative Peptides
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CHL1 Recombinant Protein (OPCD02209) - OPCD02209 from Aviva Systems Biology
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Human CHL-1 Protein (His Tag) - 10143-H08H from ABclonal
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CHL-1, Recombinant Protein - MBS2546488 from MyBioSource
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CHL-1, Recombinant Protein - MBS2546634 from MyBioSource
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CHL-1, Recombinant Protein - MBS2546635 from MyBioSource
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