CHL1
| Gene Symbol | CHL1 |
|---|---|
| Entrez Gene | 10752 |
| Alt Symbol | CALL, L1CAM2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell adhesion molecule L1-like |
| Other Description | L1 cell adhesion molecule 2|cell adhesion molecule with homology to L1CAM (close homolog of L1)|cell adhesion molecule with homology to L1CAM (close homologue of L1)|close homolog of L1|neural cell adhesion molecule L1-like protein |
| Swissprots | B7ZL03 O00533 Q59FY0 Q2M3G2 |
| Accessions | EAW63868 EAW63869 O00533 AB209329 BAD92566 AF002246 AAB60937 AK055236 AK126878 BAG54387 AL359583 BC104918 AAI04919 BC143496 AAI43497 BC143498 BF056756 CR749682 DA778898 R40400 XM_006712938 XP_006713001 XM_006712939 XP_006713002 XM_006712940 XP_006713003 XM_011533292 XP_011531594 XM_011533293 XP_011531595 XM_011533294 XP_011531596 XM_011533295 XP_011531597 XM_011533296 XP_011531598 XM_011533297 XP_011531599 NM_001253387 NP_001240316 NM_001253388 NP_001240317 NM_006614 NP_006605 NR_045572 |
| Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Soluble forms produced by cleavage/shedding also exist. {ECO:0000250}. |
| Tissue Specificity | Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. {ECO:0000269|PubMed:9799093}. |
CHL1 CRISPR/Cas9 KO Plasmid (h) - sc-403240 from Santa Cruz Biotechnology
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CHL1 HDR Plasmid (h) - sc-403240-HDR from Santa Cruz Biotechnology
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CHL1 Double Nickase Plasmid (h) - sc-403240-NIC from Santa Cruz Biotechnology
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CHL1 Double Nickase Plasmid (h2) - sc-403240-NIC-2 from Santa Cruz Biotechnology
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CHL1 CRISPR Activation Plasmid (h) - sc-403240-ACT from Santa Cruz Biotechnology
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CHL1 CRISPR Activation Plasmid (h2) - sc-403240-ACT-2 from Santa Cruz Biotechnology
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CHL1 Lentiviral Activation Particles (h) - sc-403240-LAC from Santa Cruz Biotechnology
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CHL1 Lentiviral Activation Particles (h2) - sc-403240-LAC-2 from Santa Cruz Biotechnology
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CHL1 siRNA (h) - sc-45787 from Santa Cruz Biotechnology
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CHL1 shRNA Plasmid (h) - sc-45787-SH from Santa Cruz Biotechnology
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CHL1 shRNA (h) Lentiviral Particles - sc-45787-V from Santa Cruz Biotechnology
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CHL-1/L1CAM-2 RNAi - H00010752-R01 from Novus Biologicals
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MISSION® esiRNA - EHU018221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6065 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6065 from Sigma-Aldrich
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CHL1 siRNA (Human) - CRH7327 from Cohesion Biosciences
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CHL1 - MBS8225511 from MyBioSource
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shRNA set against Human CHL1 (NM_006614.3) - SHH263133 from Creative biogene
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Human CHL1 siRNA - orb267829 from Biorbyt
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CHL1 shRNA Plasmid (Human) - CHH7327 from Cohesion Biosciences
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CHL1 miRNA 3'UTR clone - MiUTR4H-TG02078 from Creative biogene
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