Gene Symbol | Mapt |
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Entrez Gene | 17762 |
Alt Symbol | AI413597, AW045860, Mtapt, Tau |
Species | Mouse |
Gene Type | protein-coding |
Description | microtubule-associated protein tau |
Other Description | PHF-tau|neurofibrillary tangle protein|paired helical filament-tau |
Swissprots | Q60685 P10637 P10638 Q91WK4 Q60686 A2A5Y9 Q62286 Q60684 |
Accessions | BAA18878 BAC20951 BAC20952 EDL34210 EDL34211 EDL34212 EDL34213 EDL34214 EDL34215 EDL34216 EDL34217 P10637 AF483518 AAL90792 AF483519 AAL90793 AK038797 AK078167 BAC37157 AK135147 AK147636 BAE28038 BC014748 AAH14748 BI202659 BM950831 BY249380 CA450773 CO432693 M18775 AAA40165 M18776 AAA40166 M93266 U12914 AAA58343 U12915 AAA58344 U12916 AAA58345 W18770 Z12133 CAA78121 XM_006514928 XP_006514991 XM_006514929 XP_006514992 XM_006514930 XP_006514993 XM_006514931 XP_006514994 XM_006532407 XP_006532470 XM_006532408 XP_006532471 XM_006532409 XP_006532472 XM_006532410 XP_006532473 XM_011248785 XP_011247087 XM_011248786 XP_011247088 XM_011248787 XP_011247089 XM_011248788 XP_011247090 XM_011251345 XP_011249647 XM_011251346 XP_011249648 XM_011251347 XP_011249649 XM_011251348 XP_011249650 NM_001038609 NP_001033698 NM_001285454 NP_001272383 NM_001285455 NP_001272384 NM_001285456 NP_001272385 NM_010838 NP_034968 |
Function | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
Subcellular Location | Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. |
Tissue Specificity | Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. |
Top Pathways | Alzheimer's disease, MAPK signaling pathway |
Tau CRISPR/Cas9 KO Plasmid (m) - sc-421735 from Santa Cruz Biotechnology
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Tau HDR Plasmid (m) - sc-421735-HDR from Santa Cruz Biotechnology
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Tau Double Nickase Plasmid (m) - sc-421735-NIC from Santa Cruz Biotechnology
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Tau Double Nickase Plasmid (m2) - sc-421735-NIC-2 from Santa Cruz Biotechnology
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Tau CRISPR Activation Plasmid (m) - sc-421735-ACT from Santa Cruz Biotechnology
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Tau CRISPR Activation Plasmid (m2) - sc-421735-ACT-2 from Santa Cruz Biotechnology
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Tau Lentiviral Activation Particles (m) - sc-421735-LAC from Santa Cruz Biotechnology
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Tau Lentiviral Activation Particles (m2) - sc-421735-LAC-2 from Santa Cruz Biotechnology
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Tau siRNA (m) - sc-36615 from Santa Cruz Biotechnology
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Tau shRNA Plasmid (m) - sc-36615-SH from Santa Cruz Biotechnology
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Tau shRNA (m) Lentiviral Particles - sc-36615-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN35278 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35278 from Sigma-Aldrich
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MAPT siRNA (Mouse) - CRM2633 from Cohesion Biosciences
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shRNA set against Mouse MAPT (NM_010838.3) - SHH338231 from Creative biogene
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shRNA set against Mouse Mapt(NM_001038609.1) - SHH176833 from Creative biogene
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shRNA set against Mouse Mapt(NM_010838.3) - SHH176951 from Creative biogene
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Mouse MAPT siRNA - orb282109 from Biorbyt
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MAPT shRNA Plasmid (Mouse) - CHM2633 from Cohesion Biosciences
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MAPT miRNA 3'UTR clone - MiUTR1M-06947 from Creative biogene
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