SGMS1

Gene Symbol	SGMS1
Entrez Gene	259230
Alt Symbol	MOB, MOB1, SMS1, TMEM23, hmob33
Species	Human
Gene Type	protein-coding
Description	sphingomyelin synthase 1
Other Description	medulla oblongata-derived protein|phosphatidylcholine:ceramide cholinephosphotransferase 1|protein Mob|transmembrane protein 23
Swissprots	Q6EKK0 Q86VZ5 Q75SP1 Q68U43
Accessions	EAW80429 EAW80430 EAW80431 EAW80432 Q86VZ5 AB154421 BAD16809 AK026683 AK296233 BAG58954 AK311737 AY280959 AAP37279 AY312431 AAQ82051 AY332650 AAQ22363 AY364088 AAR13294 BC042899 AAH42899 BM141853 BM764008 BN000143 CAD79708 FM210200 CAR65042 FN870365 CBM41470 FN908045 CBM42040 FN908146 CBM43071 FN985166 FN994181 FR686760 CBW52777 Y14155 XM_005269675 XP_005269732 XM_011539582 XP_011537884 XM_011539583 XP_011537885 XM_011539584 XP_011537886 XM_011539585 XP_011537887 XR_945650 XR_945651 NM_147156 NP_671512
Function	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}; Multi-pass membrane protein {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}.
Tissue Specificity	Brain, heart, kidney, liver, muscle and stomach. {ECO:0000269|PubMed:11841947, ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:15315829}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Sphingomyelin Synthase 1 full length protein - ab166087 from Abcam Category Protein Source Wheat germ Species Human

SGMS1 / TMEM23 Antibody Blocking Peptide - LS-E2528 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SGMS1 / TMEM23 Antibody Blocking Peptide - LS-E20050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sphingomyelin synthase 1 Protein - H00259230-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SGMS1-Antibody-N-term-Blocking-peptide - BP13562a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CXCL10 / IP10 recombinant protein - GTX65153 from GeneTex Category Protein Prices $249.00 Sizes 25 μg Source E. coli Species Human

SMS1 peptide - orb108434 from Biorbyt Category Peptide Prices $374.00 Sizes 50 μg Species Human

SGMS1 Blocking Peptide - 33R-8327 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TMEM23 / SGMS1 - H00259230-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TMEM23 / SGMS1 - H00259230-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TMEM23 / SGMS1 control peptide - AP05279CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SGMS1 fusion protein - ag5246 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SGMS1 fusion protein - ag5253 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SGMS1 Peptide (OEEG01151) - OEEG01151 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg Species Human

Sphingomyelin Synthase 1 (SMS1), Peptide - MBS396391 from MyBioSource Category Peptide Prices $195.00 Sizes 50 µg Species Human

Sphingomyelin synthase 1 Recombinant Protein Antigen - NBP1-92435PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SGMS1 Peptide, Human - M34GP14140H from Creative Peptides Category Peptide Source Synthetic. Species Human

Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1), Recombinant Protein - MBS7029691 from MyBioSource Category Protein Prices $1,225.00, $2,210.00, $3,415.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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