SGMS1

Gene Symbol	SGMS1
Entrez Gene	259230
Alt Symbol	MOB, MOB1, SMS1, TMEM23, hmob33
Species	Human
Gene Type	protein-coding
Description	sphingomyelin synthase 1
Other Description	medulla oblongata-derived protein|phosphatidylcholine:ceramide cholinephosphotransferase 1|protein Mob|transmembrane protein 23
Swissprots	Q6EKK0 Q86VZ5 Q75SP1 Q68U43
Accessions	EAW80429 EAW80430 EAW80431 EAW80432 Q86VZ5 AB154421 BAD16809 AK026683 AK296233 BAG58954 AK311737 AY280959 AAP37279 AY312431 AAQ82051 AY332650 AAQ22363 AY364088 AAR13294 BC042899 AAH42899 BM141853 BM764008 BN000143 CAD79708 FM210200 CAR65042 FN870365 CBM41470 FN908045 CBM42040 FN908146 CBM43071 FN985166 FN994181 FR686760 CBW52777 Y14155 XM_005269675 XP_005269732 XM_011539582 XP_011537884 XM_011539583 XP_011537885 XM_011539584 XP_011537886 XM_011539585 XP_011537887 XR_945650 XR_945651 NM_147156 NP_671512
Function	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}; Multi-pass membrane protein {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}.
Tissue Specificity	Brain, heart, kidney, liver, muscle and stomach. {ECO:0000269|PubMed:11841947, ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:15315829}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMS1 (E-5) - sc-166436 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SMS1 (F-10) - sc-166380 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SMS1 (G-8) - sc-133135 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SMS1 (H-130) - sc-67097 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SMS1 (L-12) - sc-34046 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SMS1 (S-12) - sc-34047 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Sphingomyelin Synthase 1 antibody - ab83856 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Sphingomyelin Synthase 1 antibody - ab135365 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody - LS-C140565 from LifeSpan Bioscience Prices $460.00 Sizes 10 blot Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody - LS-C140518 from LifeSpan Bioscience Prices $460.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa144-193) - LS-C102650 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody - LS-C333925 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53) - LS-C169044 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody - LS-C26837 from LifeSpan Bioscience Prices $460.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, AP) - LS-C240694 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, Biotin) - LS-C240696 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, APC) - LS-C240695 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, FITC) - LS-C240697 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, PE) - LS-C240698 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa24-53, Azide-free, HRP) - LS-C248138 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa17-47) - LS-C325061 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SGMS1 / TMEM23 Antibody (aa154-203) - LS-C151318 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Sphingomyelin synthase 1 Antibody - NBP1-60081 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Sphingomyelin synthase 1 Antibody - NBP1-92435 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Sphingomyelin Synthase 1 Antibody - bs-4216R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit

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