SGMS1

Gene Symbol SGMS1
Entrez Gene 259230
Alt Symbol MOB, MOB1, SMS1, TMEM23, hmob33
Species Human
Gene Type protein-coding
Description sphingomyelin synthase 1
Other Description medulla oblongata-derived protein|phosphatidylcholine:ceramide cholinephosphotransferase 1|protein Mob|transmembrane protein 23
Swissprots Q6EKK0 Q86VZ5 Q75SP1 Q68U43
Accessions EAW80429 EAW80430 EAW80431 EAW80432 Q86VZ5 AB154421 BAD16809 AK026683 AK296233 BAG58954 AK311737 AY280959 AAP37279 AY312431 AAQ82051 AY332650 AAQ22363 AY364088 AAR13294 BC042899 AAH42899 BM141853 BM764008 BN000143 CAD79708 FM210200 CAR65042 FN870365 CBM41470 FN908045 CBM42040 FN908146 CBM43071 FN985166 FN994181 FR686760 CBW52777 Y14155 XM_005269675 XP_005269732 XM_011539582 XP_011537884 XM_011539583 XP_011537885 XM_011539584 XP_011537886 XM_011539585 XP_011537887 XR_945650 XR_945651 NM_147156 NP_671512
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location Golgi apparatus membrane {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}; Multi-pass membrane protein {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912, ECO:0000269|PubMed:18694848}.
Tissue Specificity Brain, heart, kidney, liver, muscle and stomach. {ECO:0000269|PubMed:11841947, ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:15315829}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SMS1 CRISPR/Cas9 KO Plasmid (h) - sc-403382 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 HDR Plasmid (h) - sc-403382-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 Double Nickase Plasmid (h) - sc-403382-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 Double Nickase Plasmid (h2) - sc-403382-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 CRISPR Activation Plasmid (h) - sc-403382-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 CRISPR Activation Plasmid (h2) - sc-403382-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 Lentiviral Activation Particles (h) - sc-403382-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 Lentiviral Activation Particles (h2) - sc-403382-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMS1 siRNA (h) - sc-44428 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMS1 shRNA Plasmid (h) - sc-44428-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMS1 shRNA (h) Lentiviral Particles - sc-44428-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sphingomyelin synthase 1 RNAi - H00259230-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU126521 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19231 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19231 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10007 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10007

SGMS1 siRNA (Human) - CRJ6801 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SGMS1 - MBS8224528 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SGMS1 (NM_147156.3) - SHH406300 from Creative biogene

Category siRNA
Species Reactivities Human

Human SGMS1 siRNA - orb277302 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SGMS1 shRNA Plasmid (Human) - CHJ6801 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SGMS1 miRNA 3'UTR clone - MiUTR1H-09351 from Creative biogene

Species Reactivities Human
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