| Gene Symbol | MAP3K5 |
|---|---|
| Entrez Gene | 4217 |
| Alt Symbol | ASK1, MAPKKK5, MEKK5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase kinase 5 |
| Other Description | ASK-1|MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|MEK kinase 5|MEKK 5|apoptosis signal regulating kinase 1|apoptosis signal-regulating kinase 1 |
| Swissprots | B4DGB2 Q5THN3 Q99683 A6NIA0 Q99461 |
| Accessions | AAT52164 EAW47942 Q99683 AB209093 BAD92330 AK293953 BAG57328 AK294507 BAG57723 AK310942 BC054503 AAH54503 BC088829 AAH88829 D84476 BAA12684 U67156 AAC50894 XM_011535837 XP_011534139 XM_011535838 XP_011534140 XM_011535839 XP_011534141 NM_005923 NP_005914 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 |
| Subcellular Location | Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. |
| Tissue Specificity | Abundantly expressed in heart and pancreas. |
| Top Pathways | Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway, Protein processing in endoplasmic reticulum, TNF signaling pathway |
Human MAP3K5 / ASK1 ELISA Kit (Sandwich ELISA) - LS-F4572 from LifeSpan Bioscience
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Mouse/Human/Rat MAP3K5 / ASK1 ELISA Kit (Cell-Based ELISA) - LS-F1806 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-MAP3K5 / ASK1 (Ser966) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1451 from LifeSpan Bioscience
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Human Phospho-MAP3K5 / ASK1 (Ser83) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1450 from LifeSpan Bioscience
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Human ASK-1 ELISA Kit - abx054479 from Abbexa
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Human ASK1 ELISA Kit - abx150753 from Abbexa
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Apoptosis Signal Regulating Kinase 1 (ASK1), Human, ELISA Kit - SEB358Hu from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, Human, ELISA Kit - E01A0379 from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK-1, Human, ELISA Kit - E-EL-H0482 from ARP American Research Products
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Mitogen-activated protein kinase kinase kinase 5, MAP3K5, Human, ELISA Kit - E1358h from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK1, Mouse, ELISA Kit - E-EL-M0142 from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK-1, Rabbit, ELISA Kit - E-EL-RB0145 from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK-1, Chicken, ELISA Kit - E-EL-Ch1793 from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK-1, Porcine, ELISA Kit - E-EL-P0318 from ARP American Research Products
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Apoptosis Signal Regulating Kinase 1, ASK-1, Monkey, ELISA Kit - E-EL-MK1598 from ARP American Research Products
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Human ASK1 ELISA Kit - HA0386 from NeoScientific
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Anserine ASK1 ELISA Kit - AA0386 from NeoScientific
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS066305 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS033802 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS752155 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS101436 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS753232 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS751208 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS032644 from MyBioSource
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Apoptosis Signal Regulating Kinase 1, ELISA Kit - MBS754310 from MyBioSource
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