MAP3K5

Gene Symbol	MAP3K5
Entrez Gene	4217
Alt Symbol	ASK1, MAPKKK5, MEKK5
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 5
Other Description	ASK-1|MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|MEK kinase 5|MEKK 5|apoptosis signal regulating kinase 1|apoptosis signal-regulating kinase 1
Swissprots	B4DGB2 Q5THN3 Q99683 A6NIA0 Q99461
Accessions	AAT52164 EAW47942 Q99683 AB209093 BAD92330 AK293953 BAG57328 AK294507 BAG57723 AK310942 BC054503 AAH54503 BC088829 AAH88829 D84476 BAA12684 U67156 AAC50894 XM_011535837 XP_011534139 XM_011535838 XP_011534140 XM_011535839 XP_011534141 NM_005923 NP_005914
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7
Subcellular Location	Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Tissue Specificity	Abundantly expressed in heart and pancreas.
Top Pathways	Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway, Protein processing in endoplasmic reticulum, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ASK1 protein fragment - ab60325 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human ASK1 protein fragment - ab152525 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E3285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E30204 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E30205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E29855 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E9364 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K5 / ASK1 Antibody Blocking Peptide - LS-E9363 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ASK1 Partial Recombinant Protein - H00004217-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ASK1 [p Ser83] Peptide - NBP1-96993 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

ASK1 Peptide - NBP1-96992 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

Recombinant Human ASK1 Protein - P4194 from Novus Biologicals Category Protein Prices $549.00, $670.00 Sizes 5 µg, 5 µg Source Insect Species Human

ASK1 Peptide - NBP1-76420PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

ASK1 Blocking Peptide - NBP1-76674PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

ASK1 Peptide - NBP1-77032PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

ASK1 Protein - NBP1-99880 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

ASK1 Peptide - P2892 from Novus Biologicals Category Peptide Species Human

ASK1 Peptide - P2891 from Novus Biologicals Category Peptide Species Human

ASK1-MEKK5MAP3K5-Antibody-S966-Blocking-peptide - BP7911f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ASK1-MEKK5MAP3K5-Antibody-S83-Blocking-peptide - BP7911e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ASK1 (active) recombinant protein - GTX65170 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active ASK1 (aa 649-946), CF - 3575-KS-010 from R&D Systems Category Protein

ASK1 protein - 30R-2825 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

ASK1 Blocking Peptide - abx062928 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

ASK1 Blocking Peptide - abx062162 from Abbexa Category Peptide Species Human, Mouse, Rat

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