| Gene Symbol |
NAT10
|
| Entrez Gene |
55226
|
| Alt Symbol |
ALP, NET43
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetyltransferase 10 (GCN5-related)
|
| Other Description |
N-acetyltransferase 10|N-acetyltransferase-like protein
|
| Swissprots |
Q9H0A0 Q9NVF2 Q9C0F4 Q9HA61 E9PMN9 Q86WK5 E7ESU4 B4DFD5
|
| Accessions |
EAW68174 EAW68175 Q9H0A0 AB051496 BAB21800 AF489535 AAO49126 AK001636 BAA91800 AK022241 BAB13995 AK074430 AK225341 AK294044 BAG57396 AL136882 CAB66816 AM393096 CAL37974 BC014440 BC020205 AAH20205 BC035558 AAH35558 BM988569 CN336530 XM_011520197 XP_011518499 NM_001144030 NP_001137502 NM_024662 NP_078938
|
| Function |
Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division. {ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:19303003}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase.
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|
![Western Blot: NAT10 Overexpression Lysate (Adult Normal) [NBL1-13485] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NAT10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7952_NAT10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13485-img0002.jpg)