Gene Symbol | NAT10 |
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Entrez Gene | 55226 |
Alt Symbol | ALP, NET43 |
Species | Human |
Gene Type | protein-coding |
Description | N-acetyltransferase 10 (GCN5-related) |
Other Description | N-acetyltransferase 10|N-acetyltransferase-like protein |
Swissprots | Q9H0A0 Q9NVF2 Q9C0F4 Q9HA61 E9PMN9 Q86WK5 E7ESU4 B4DFD5 |
Accessions | EAW68174 EAW68175 Q9H0A0 AB051496 BAB21800 AF489535 AAO49126 AK001636 BAA91800 AK022241 BAB13995 AK074430 AK225341 AK294044 BAG57396 AL136882 CAB66816 AM393096 CAL37974 BC014440 BC020205 AAH20205 BC035558 AAH35558 BM988569 CN336530 XM_011520197 XP_011518499 NM_001144030 NP_001137502 NM_024662 NP_078938 |
Function | Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division. {ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:19303003}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. |
Top Pathways | Ribosome biogenesis in eukaryotes |
NAT-10 CRISPR/Cas9 KO Plasmid (h) - sc-406713 from Santa Cruz Biotechnology
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NAT-10 HDR Plasmid (h) - sc-406713-HDR from Santa Cruz Biotechnology
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NAT-10 Double Nickase Plasmid (h) - sc-406713-NIC from Santa Cruz Biotechnology
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NAT-10 Double Nickase Plasmid (h2) - sc-406713-NIC-2 from Santa Cruz Biotechnology
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NAT-10 CRISPR Activation Plasmid (h) - sc-406713-ACT from Santa Cruz Biotechnology
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NAT-10 CRISPR Activation Plasmid (h2) - sc-406713-ACT-2 from Santa Cruz Biotechnology
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NAT-10 Lentiviral Activation Particles (h) - sc-406713-LAC from Santa Cruz Biotechnology
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NAT-10 Lentiviral Activation Particles (h2) - sc-406713-LAC-2 from Santa Cruz Biotechnology
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NAT-10 siRNA (h) - sc-62660 from Santa Cruz Biotechnology
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NAT-10 shRNA Plasmid (h) - sc-62660-SH from Santa Cruz Biotechnology
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NAT-10 shRNA (h) Lentiviral Particles - sc-62660-V from Santa Cruz Biotechnology
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NAT10 RNAi - H00055226-R01 from Novus Biologicals
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MISSION® esiRNA - EHU028361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14965 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14965 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05810 from Sigma-Aldrich
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NAT10 siRNA (Human) - CRJ0575 from Cohesion Biosciences
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shRNA set against Human NAT10 (NM_024662.2) - SHH349448 from Creative biogene
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Human NAT10 siRNA - orb271076 from Biorbyt
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NAT10 shRNA Plasmid (Human) - CHJ0575 from Cohesion Biosciences
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NAT10 miRNA 3'UTR clone - MiUTR3H-10490 from Creative biogene
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NAT10 miRNA 3'UTR clone - MiUTR3H-10491 from Creative biogene
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