| Gene Symbol |
IFI16
|
| Entrez Gene |
3428
|
| Alt Symbol |
IFNGIP1, PYHIN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon, gamma-inducible protein 16
|
| Other Description |
gamma-interferon-inducible protein 16|interferon-gamma induced protein IFI 16|interferon-inducible myeloid differentiation transcriptional activator
|
| Swissprots |
Q8NEQ7 Q5T3X2 Q16666 Q59GX0 H3BLV7 Q9UH78 Q96AJ5 B4DJT8 Q5T3W7 Q5T3W8 Q5T3X0 Q8N9E5 Q5T3X1
|
| Accessions |
AAB32519 EAW52797 EAW52798 EAW52799 EAW52800 EAW52801 EAW52802 EAW52803 Q16666 AB208989 BAD92226 AF086545 AF208043 AAF20997 AK094968 BAC04462 AK296228 BAG58950 AK307957 AY138863 AAM96005 BC017059 AAH17059 BM806453 BM993134 DA945454 DA990524 DB273519 DQ891062 ABM81988 DQ894242 ABM85168 M63838 AAA58683 XM_005245127 XP_005245184 XM_006711290 XP_006711353 XM_011509478 XP_011507780 NM_001206567 NP_001193496 NM_005531 NP_005522
|
| Function |
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.
|
| Tissue Specificity |
Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level). {ECO:0000269|PubMed:12894224}.
|