IFI16

Gene Symbol	IFI16
Entrez Gene	3428
Alt Symbol	IFNGIP1, PYHIN2
Species	Human
Gene Type	protein-coding
Description	interferon, gamma-inducible protein 16
Other Description	gamma-interferon-inducible protein 16|interferon-gamma induced protein IFI 16|interferon-inducible myeloid differentiation transcriptional activator
Swissprots	Q8NEQ7 Q5T3X2 Q16666 Q59GX0 H3BLV7 Q9UH78 Q96AJ5 B4DJT8 Q5T3W7 Q5T3W8 Q5T3X0 Q8N9E5 Q5T3X1
Accessions	AAB32519 EAW52797 EAW52798 EAW52799 EAW52800 EAW52801 EAW52802 EAW52803 Q16666 AB208989 BAD92226 AF086545 AF208043 AAF20997 AK094968 BAC04462 AK296228 BAG58950 AK307957 AY138863 AAM96005 BC017059 AAH17059 BM806453 BM993134 DA945454 DA990524 DB273519 DQ891062 ABM81988 DQ894242 ABM85168 M63838 AAA58683 XM_005245127 XP_005245184 XM_006711290 XP_006711353 XM_011509478 XP_011507780 NM_001206567 NP_001193496 NM_005531 NP_005522
Function	Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral
Subcellular Location	Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.
Tissue Specificity	Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level). {ECO:0000269|PubMed:12894224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IFI16 full length protein - ab158724 from Abcam Category Protein Source Wheat germ Species Human

Human IFI16 protein fragment - ab114542 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human IFI16 Protein - H00003428-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IFI16 Protein - H00003428-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Human IFI16 Protein - abx067370 from Abbexa Category Protein Source E.coli Species Human

IFI16 / IFNGIP1 - H00003428-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

IFI16 / IFNGIP1 - H00003428-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IFI16 / IFNGIP1 - H00003428-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IFI16 fusion protein - Ag3102 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human IFI16 - IFI16-26947TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human IFI16, GST-tagged - IFI16-14060H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Interferon Gamma Inducible Protein 16 (IFI16) - RPB900Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

IFI-16 (N772) Peptide - BS3865P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Interferon Gamma Inducible Protein 16 (IFI16) - RPB900Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Gamma-interferon-inducible protein 16(IFI16) - CSB-YP620975HU CSB-EP620975HU CSB-BP620975HU CSB-MP620975HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IFI16 / IFNGIP1 - TP302193 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IFI16 Recombinant Protein Antigen - NBP1-83118PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IFI16 Peptide, Human - M34GP07416H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gamma-interferon-inducible protein 16 (IFI16), Recombinant Protein - MBS1309983 from MyBioSource Category Protein Prices $1,615.00, $1,615.00, $1,845.00, $1,845.00, $2,730.00, $2,730.00, $3,185.00, $3,185.00, $3,185.00, $5,395.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

IFI16 Recombinant Protein (OPCD04105) - OPCD04105 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human IFI16 protein, His & T7-tagged - IFI16-1946H from Creative Biomart Category Protein Source E. coli Species Human

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