IFI16

Gene Symbol	IFI16
Entrez Gene	3428
Alt Symbol	IFNGIP1, PYHIN2
Species	Human
Gene Type	protein-coding
Description	interferon, gamma-inducible protein 16
Other Description	gamma-interferon-inducible protein 16|interferon-gamma induced protein IFI 16|interferon-inducible myeloid differentiation transcriptional activator
Swissprots	Q8NEQ7 Q5T3X2 Q16666 Q59GX0 H3BLV7 Q9UH78 Q96AJ5 B4DJT8 Q5T3W7 Q5T3W8 Q5T3X0 Q8N9E5 Q5T3X1
Accessions	AAB32519 EAW52797 EAW52798 EAW52799 EAW52800 EAW52801 EAW52802 EAW52803 Q16666 AB208989 BAD92226 AF086545 AF208043 AAF20997 AK094968 BAC04462 AK296228 BAG58950 AK307957 AY138863 AAM96005 BC017059 AAH17059 BM806453 BM993134 DA945454 DA990524 DB273519 DQ891062 ABM81988 DQ894242 ABM85168 M63838 AAA58683 XM_005245127 XP_005245184 XM_006711290 XP_006711353 XM_011509478 XP_011507780 NM_001206567 NP_001193496 NM_005531 NP_005522
Function	Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral
Subcellular Location	Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.
Tissue Specificity	Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level). {ECO:0000269|PubMed:12894224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IFI16 Antibody - 8079 from Cell Signaling Technology Prices $239.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

IFI-16 (1G7) - sc-8023 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IFI-16 (H-8) - sc-136976 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IFI-16 (C-18) - sc-6050 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IFI-16 (D-1) - sc-166504 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IFI-16 (G-4) - sc-166472 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IFI-16 (H-55) - sc-50359 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-IFI16 antibody - ab55328 from Abcam Prices $400.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-IFI16 antibody - ab185812 from Abcam Prices $378.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-IFI16 antibody - ab168298 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-IFI16 antibody - ab136836 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 antibody - ab140814 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 antibody [EPR11767(B)] - ab169788 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11767(B)

Anti-IFI16 antibody [IFI-230] - ab50004 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone IFI-230

Anti-IFI16 Antibody (clone 2C2) - LS-C133265 from LifeSpan Bioscience Prices $355.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2C2

Anti-IFI16 Antibody (clone 2E3) IHC-plus™ - LS-B11853 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2E3

Anti-IFI16 Antibody (aa731-780) - LS-C119992 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody (aa723-772) - LS-C292084 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody - LS-C310691 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody (aa630-730, Azide-free) - LS-C327601 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-IFI16 Antibody - LS-C341225 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody IHC-plus™ - LS-B7817 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody (Asn772) - LS-C177840 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody (aa465-671) - LS-C294764 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IFI16 Antibody (aa386-435) - LS-C206147 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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