Gene Symbol | ZFP57 |
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Entrez Gene | 346171 |
Alt Symbol | C6orf40, TNDM1, ZNF698, bA145L22, bA145L22.2 |
Species | Human |
Gene Type | protein-coding |
Description | ZFP57 zinc finger protein |
Other Description | zfp-57|zinc finger protein 57 homolog|zinc finger protein 698 |
Swissprots | B0S894 Q5SSB1 Q9NU63 B0V254 B2RXJ7 |
Accessions | CAB89275 Q9NU63 BC157878 AAI57879 BC171888 AAI71888 BC172354 AAI72354 XM_006715087 XP_006715150 XM_006725485 XP_006725548 XM_006725487 XP_006725550 XM_006725701 XP_006725764 XM_006725818 XP_006725881 XM_006725910 XP_006725973 XM_006726000 XP_006726063 XM_006726093 XP_006726156 XM_011514570 XP_011512872 XM_011547248 XP_011545550 XM_011547249 XP_011545551 XM_011548049 XP_011546351 XM_011548432 XP_011546734 NM_001109809 NP_001103279 |
Function | Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. {ECO:0000250, ECO:0000269|PubMed:18622393}. |
Subcellular Location | Nucleus {ECO:0000250}. Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR. {ECO:0000250}. |
ZFP57 CRISPR/Cas9 KO Plasmid (h) - sc-404270 from Santa Cruz Biotechnology
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ZFP57 HDR Plasmid (h) - sc-404270-HDR from Santa Cruz Biotechnology
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ZFP57 Double Nickase Plasmid (h) - sc-404270-NIC from Santa Cruz Biotechnology
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ZFP57 Double Nickase Plasmid (h2) - sc-404270-NIC-2 from Santa Cruz Biotechnology
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ZFP57 CRISPR Activation Plasmid (h) - sc-404270-ACT from Santa Cruz Biotechnology
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ZFP57 CRISPR Activation Plasmid (h2) - sc-404270-ACT-2 from Santa Cruz Biotechnology
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ZFP57 Lentiviral Activation Particles (h) - sc-404270-LAC from Santa Cruz Biotechnology
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ZFP57 Lentiviral Activation Particles (h2) - sc-404270-LAC-2 from Santa Cruz Biotechnology
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ZFP57 siRNA (h) - sc-95179 from Santa Cruz Biotechnology
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ZFP57 shRNA Plasmid (h) - sc-95179-SH from Santa Cruz Biotechnology
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ZFP57 shRNA (h) Lentiviral Particles - sc-95179-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU227581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23187 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23187 from Sigma-Aldrich
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ZFP57 siRNA (Human) - CRJ7479 from Cohesion Biosciences
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ZFP57 - MBS8227838 from MyBioSource
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shRNA set against Human Zfp57 (NM_001109809.2) - SHH451456 from Creative biogene
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Human ZFP57 siRNA - orb277980 from Biorbyt
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ZFP57 shRNA Plasmid (Human) - CHJ7479 from Cohesion Biosciences
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