| Gene Symbol |
DNTT
|
| Entrez Gene |
1791
|
| Alt Symbol |
TDT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA nucleotidylexotransferase
|
| Other Description |
deoxynucleotidyltransferase, terminal|nucleosidetriphosphate:DNA deoxynucleotidylexotransferase|terminal addition enzyme|terminal deoxynucleotidyltransferase|terminal deoxyribonucleotidyltransferase|terminal transferase
|
| Swissprots |
P04053 Q5W103 Q53FH1 Q96E50
|
| Accessions |
AAA61137 EAW49979 P04053 AB046378 BAB72001 AK130771 AK223317 BAD97037 AK313615 BC012920 AAH12920 DQ891465 ABM82391 DQ894645 ABM85571 K01919 AAA61136 M20694 AAA53100 M20695 M20696 M20697 M20698 M20699 M20700 M20701 M20702 M20703 M22968 M26144 AAA74588 XM_011539420 XP_011537722 NM_001017520 NP_001017520 NM_004088 NP_004079
|
| Function |
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Hematopoietic cell lineage, Non-homologous end-joining
|
![Western Blot: TdT Overexpression Lysate (Adult Normal) [NBP2-10562] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TdT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2261_TdT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10562-img0001.jpg)