Gene Symbol | DNTT |
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Entrez Gene | 1791 |
Alt Symbol | TDT |
Species | Human |
Gene Type | protein-coding |
Description | DNA nucleotidylexotransferase |
Other Description | deoxynucleotidyltransferase, terminal|nucleosidetriphosphate:DNA deoxynucleotidylexotransferase|terminal addition enzyme|terminal deoxynucleotidyltransferase|terminal deoxyribonucleotidyltransferase|terminal transferase |
Swissprots | P04053 Q5W103 Q53FH1 Q96E50 |
Accessions | AAA61137 EAW49979 P04053 AB046378 BAB72001 AK130771 AK223317 BAD97037 AK313615 BC012920 AAH12920 DQ891465 ABM82391 DQ894645 ABM85571 K01919 AAA61136 M20694 AAA53100 M20695 M20696 M20697 M20698 M20699 M20700 M20701 M20702 M20703 M22968 M26144 AAA74588 XM_011539420 XP_011537722 NM_001017520 NP_001017520 NM_004088 NP_004079 |
Function | Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. |
Subcellular Location | Nucleus. |
Top Pathways | Hematopoietic cell lineage, Non-homologous end-joining |
TdT CRISPR/Cas9 KO Plasmid (h) - sc-406822 from Santa Cruz Biotechnology
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TdT HDR Plasmid (h) - sc-406822-HDR from Santa Cruz Biotechnology
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TdT Double Nickase Plasmid (h) - sc-406822-NIC from Santa Cruz Biotechnology
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TdT Double Nickase Plasmid (h2) - sc-406822-NIC-2 from Santa Cruz Biotechnology
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TdT CRISPR Activation Plasmid (h) - sc-406822-ACT from Santa Cruz Biotechnology
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TdT CRISPR Activation Plasmid (h2) - sc-406822-ACT-2 from Santa Cruz Biotechnology
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TdT Lentiviral Activation Particles (h) - sc-406822-LAC from Santa Cruz Biotechnology
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TdT Lentiviral Activation Particles (h2) - sc-406822-LAC-2 from Santa Cruz Biotechnology
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TdT siRNA (h) - sc-44143 from Santa Cruz Biotechnology
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TdT shRNA Plasmid (h) - sc-44143-SH from Santa Cruz Biotechnology
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TdT shRNA (h) Lentiviral Particles - sc-44143-V from Santa Cruz Biotechnology
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TdT RNAi - H00001791-R02 from Novus Biologicals
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MISSION® esiRNA - EHU037021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7409 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7409 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02562 from Sigma-Aldrich
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DNTT siRNA (Human) - CRH1245 from Cohesion Biosciences
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TdT RNAi - H00001791-R01 from Novus Biologicals
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DNTT - MBS8225320 from MyBioSource
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TdT CRISPR/Cas9 KO Plasmid (h2) - sc-406822-KO-2 from Santa Cruz Biotechnology
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TdT HDR Plasmid (h2) - sc-406822-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DNTT (NM_004088.3) - SHH280061 from Creative biogene
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shRNA set against Human DNTT(NM_001017520.1) - SHH012773 from Creative biogene
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shRNA set against Human DNTT(NM_004088.3) - SHH012791 from Creative biogene
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DNTT shRNA Plasmid (Human) - CHH1245 from Cohesion Biosciences
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