| Gene Symbol |
CASP4
|
| Entrez Gene |
837
|
| Alt Symbol |
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase 4, apoptosis-related cysteine peptidase
|
| Other Description |
CASP-4|ICE(rel)-II|apoptotic cysteine protease Mih1/TX|caspase 4, apoptosis-related cysteine protease|caspase-4|protease ICH-2|protease TX
|
| Swissprots |
A2NHL8 A2NHM0 P49662
|
| Accessions |
ABR09278 CAA03154 EAW67050 EAW67051 EAW67052 EAW67053 P49662 AI128358 AK057094 BAG51861 AK225751 AK296081 BAG58837 AK304222 BAG65094 AL050391 CAB43686 BC008060 BC017839 AAH17839 CN261701 DQ891983 ABM82909 DQ895173 ABM86099 U25804 AAA86890 U28014 AAA75171 U28976 AAC99850 U28977 AAC99851 U28978 AAC99852 U28979 AAC99853 Z48810 CAA88750 XM_011543019 XP_011541321 NM_001225 NP_001216 NM_033306 NP_150649 NM_033307
|
| Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1. {ECO:0000269|PubMed:15123740, ECO:0000269|Ref.14}.
|
| Subcellular Location |
Endoplasmic reticulum membrane. Mitochondrion.
|
| Tissue Specificity |
Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
|