Gene Symbol | UGT2B4 |
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Entrez Gene | 7363 |
Alt Symbol | HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11 |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 2 family, polypeptide B4 |
Other Description | UDP-glucuronosyltransferase 2B4|UDP-glucuronyltransferase, family 2, beta-4|UDPGT 2B4|hyodeoxycholic acid|hyodeoxycholic acid-specific UDPGT |
Swissprots | A6NCP7 G5E9X8 O60867 Q1HBF9 P06133 O75614 O60731 Q6QQX7 P36538 B4DT75 |
Accessions | AAF78145 ABF47107 EAX05591 EAX05592 P06133 AF064200 AAC95002 AF081793 AAC32272 AJ005162 CAA06396 AK292748 BAF85437 AK300084 BAG61887 AY529122 AAS47487 BC026264 AAH26264 BX494777 DB185148 DQ895203 ABM86129 Y00317 CAA68415 XM_005265701 XP_005265758 NM_001297615 NP_001284544 NM_001297616 NP_001284545 NM_021139 NP_066962 |
Function | UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid. |
Subcellular Location | Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Top Pathways | Chemical carcinogenesis, Bile secretion, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450 |
Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4, UGT2B4, Human, ELISA Kit - E-EL-H1242 from ARP American Research Products
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Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4, UGT2B4, Rabbit, ELISA Kit - E-EL-RB0083 from ARP American Research Products
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Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4, UGT2B4, Chicken, ELISA Kit - E-EL-Ch1331 from ARP American Research Products
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Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4, UGT2B4, Porcine, ELISA Kit - E-EL-P0344 from ARP American Research Products
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Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4, UGT2B4, Monkey, ELISA Kit - E-EL-MK0665 from ARP American Research Products
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Human UGT2B4(Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4) ELISA Kit - E-EL-H1242 from Elabscience
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UGT2B4, ELISA Kit - MBS2513671 from MyBioSource
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UGT2B4, ELISA Kit - MBS2509923 from MyBioSource
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UGT2B4, ELISA Kit - MBS2514029 from MyBioSource
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UGT2B4, ELISA Kit - MBS2507706 from MyBioSource
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UGT2B4, ELISA Kit - MBS2508494 from MyBioSource
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uridine dipho-sphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), ELISA Kit - MBS9311339 from MyBioSource
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Human UGT2B4(Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4) ELISA Kit - E-EL-H1242 from Iwai North America Inc.
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Human UGT2B4 ELISA Kit - abx054957 from Abbexa
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Human UGT2B4 ELISA Kit - E102066 from Biobool
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Human UGT2B11 ELISA Kit - E102075 from Biobool
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UGT2B4 ELISA Kit (Human) (OKEI00209) - OKEI00209 from Aviva Systems Biology
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Human UGT2B4 ELISA Kit (Sandwich ELISA) - LS-F37927 from LifeSpan Bioscience
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Human UGT2B4 (Uridine Dipho-sphate Glucuronosyltransferase 2 Family Polypeptide B4) ELISA Kit - EKE60764 from Biomatik
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