| Gene Symbol |
UGT2B4
|
| Entrez Gene |
7363
|
| Alt Symbol |
HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide B4
|
| Other Description |
UDP-glucuronosyltransferase 2B4|UDP-glucuronyltransferase, family 2, beta-4|UDPGT 2B4|hyodeoxycholic acid|hyodeoxycholic acid-specific UDPGT
|
| Swissprots |
A6NCP7 G5E9X8 O60867 Q1HBF9 P06133 O75614 O60731 Q6QQX7 P36538 B4DT75
|
| Accessions |
AAF78145 ABF47107 EAX05591 EAX05592 P06133 AF064200 AAC95002 AF081793 AAC32272 AJ005162 CAA06396 AK292748 BAF85437 AK300084 BAG61887 AY529122 AAS47487 BC026264 AAH26264 BX494777 DB185148 DQ895203 ABM86129 Y00317 CAA68415 XM_005265701 XP_005265758 NM_001297615 NP_001284544 NM_001297616 NP_001284545 NM_021139 NP_066962
|
| Function |
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
|
| Subcellular Location |
Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Top Pathways |
Chemical carcinogenesis, Bile secretion, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450
|