HAX1
| Gene Symbol | HAX1 |
|---|---|
| Entrez Gene | 10456 |
| Alt Symbol | HCLSBP1, HS1BP1, SCN3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | HCLS1 associated protein X-1 |
| Other Description | HAX-1|HCLS1 (and PKD2) associated protein|HCLS1-associated protein X-1|HS1 binding protein|HS1-associating protein X-1|HS1-binding protein 1|HSP1BP-1 |
| Swissprots | Q5VYD7 A8W4X0 O00165 Q5VYD5 B4DUJ7 Q96AU4 A8W4W9 Q9BS80 |
| Accessions | EAW53212 O00165 AK290626 BAF83315 AK294298 BAG57580 AK300676 BAG62359 AK310000 AK311450 AK313291 BC005240 AAH05240 BC014314 AAH14314 BC015209 AAH15209 BC016730 AAH16730 BF668367 EU190982 ABW73998 EU190983 ABW73999 HQ447125 ADQ31612 JF432154 ADZ15371 U68566 AAB51196 NM_001018837 NP_001018238 NM_006118 NP_006109 |
| Function | Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. {ECO:0000269|PubMed:15339924, ECO:0000269|PubMed:16857965, ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:18319618, ECO:0000269|PubMed:18971376, ECO:0000269|PubMed:9058808}. |
| Subcellular Location | Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Up-regulated in oral cancers. {ECO:0000269|PubMed:17545607, ECO:0000269|PubMed:9058808}. |
HAX-1 CRISPR/Cas9 KO Plasmid (h) - sc-402087 from Santa Cruz Biotechnology
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HAX-1 HDR Plasmid (h) - sc-402087-HDR from Santa Cruz Biotechnology
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HAX-1 Double Nickase Plasmid (h) - sc-402087-NIC from Santa Cruz Biotechnology
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HAX-1 Double Nickase Plasmid (h2) - sc-402087-NIC-2 from Santa Cruz Biotechnology
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HAX-1 CRISPR Activation Plasmid (h) - sc-402087-ACT from Santa Cruz Biotechnology
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HAX-1 CRISPR Activation Plasmid (h2) - sc-402087-ACT-2 from Santa Cruz Biotechnology
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HAX-1 Lentiviral Activation Particles (h) - sc-402087-LAC from Santa Cruz Biotechnology
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HAX-1 Lentiviral Activation Particles (h2) - sc-402087-LAC-2 from Santa Cruz Biotechnology
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HAX-1 siRNA (h) - sc-43365 from Santa Cruz Biotechnology
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HAX-1 shRNA Plasmid (h) - sc-43365-SH from Santa Cruz Biotechnology
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HAX-1 shRNA (h) Lentiviral Particles - sc-43365-V from Santa Cruz Biotechnology
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HAX-1 RNAi - H00010456-R02 from Novus Biologicals
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MISSION® esiRNA - EHU105771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9890 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9890 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00291 from Sigma-Aldrich
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HAX1 siRNA (Human) - CRH7094 from Cohesion Biosciences
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HAX-1 RNAi - H00010456-R01 from Novus Biologicals
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HAX1 - MBS8237258 from MyBioSource
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shRNA set against Human HA (NM_006118.3) - SHH310065 from Creative biogene
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shRNA set against Human HAX1(NM_006118.3) - SHH114563 from Creative biogene
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shRNA set against Human HAX1(NM_001018837.1) - SHH114571 from Creative biogene
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shRNA set against Human HAX1(NM_006118.3) - SHH114589 from Creative biogene
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Human HAX1 siRNA - orb267596 from Biorbyt
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HAX1 shRNA Plasmid (Human) - CHH7094 from Cohesion Biosciences
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