SPEG

Gene Symbol SPEG
Entrez Gene 10290
Alt Symbol APEG-1, APEG1, BPEG, CNM5, SPEGalpha, SPEGbeta
Species Human
Gene Type protein-coding
Description SPEG complex locus
Other Description aortic preferentially expressed gene 1|aortic preferentially expressed protein 1|nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury|striated muscle preferentially expressed protein kinase
Swissprots Q695L1 A8K0G6 A8MRU0 Q6ZQW1 Q9P2P9 Q15772 Q6FGA6 Q27J74 Q6ZTL8
Accessions AAY15052 EAW70742 EAW70743 EAW70744 EAW70745 EAW70746 EAW70747 EAW70748 EAW70749 EAW70750 EAW70751 Q15772 AB037718 BAA92535 AK055387 AK098307 AK126500 BAC86568 AK128689 AK129604 AK289531 BAF82220 AL512705 AL535839 AY603755 AAT80901 BC006346 AAH06346 BM677138 CR542201 CAG46998 DA063220 DQ395348 ABD61734 U57099 AAC50599 XM_005246237 XP_005246294 XM_005246239 XP_005246296 XM_005246240 XP_005246297 XM_005246241 XP_005246298 XM_005246242 XP_005246299 XM_006712189 XP_006712252 XM_006712193 XP_006712256 XM_011510479 XP_011508781 XM_011510480 XP_011508782 XM_011510481 XP_011508783 XM_011510482 XP_011508784 XM_011510483 XP_011508785 XM_011510484 XP_011508786 XM_011510485 XP_011508787 XM_011510486 XP_011508788 NM_001173476 NP_001166947 NM_005876 NP_005867
Function Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Subcellular Location Isoform 3: Nucleus.
Tissue Specificity Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. {ECO:0000269|PubMed:15185077, ECO:0000269|PubMed:8663449}.

APEG1 (E-14) - sc-167091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-APEG1 antibody - ab168746 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-APEG1 antibody (ab168746) at 1 µg/mlLane 1 : APEG1 transfected 293T cell lysate (12.70 KDa)Lane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Anti-APEG1 antibody - ab56572 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56572 APEG1 antibody at 1ug/ml.

Anti-APEG1 antibody - ab140853 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-SPEG Antibody (clone 2C2-2C7) - LS-C306283 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C2-2C7

Anti-SPEG Antibody (aa1683-1697) - LS-C155013 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

APEG1 Antibody - NBP1-90134 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: APEG1 Antibody [NBP1-90134] - Staining of human heart muscle shows strong membranous and cytoplasmic positivity in myocytes.

APEG1 Antibody - H00010290-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: APEG1 Antibody [H00010290-B01] - analysis of APEG1 expression in transfected 293T cell line by APEG1 MaxPab polyclonal antibody (B01). Lane 1: APEG1 transfected lysate (12.70 KDa). Lane 2: Non-transfected lysate.

APEG1 Antibody (2C2-2C7) - H00010290-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C2-2C7
Western Blot: APEG1 Antibody (2C2-2C7) [H00010290-M01] - Analysis of SPEG expression in transfected 293T cell line by APEG1 monoclonal antibody (M01), clone S2.Lane 1: SPEG transfected lysate (Predicted MW: 12.7 KDa).Lane 2: Non-transfected lysate.

APEG1 Antibody - H00010290-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

APEG1 Antibody - NBP2-26072 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Monoclonal Anti-APEG1 antibody produced in mouse - WH0010290M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C2-2C7
<B>Immunoblotting</B><BR/>Monoclonal Anti-APEG1, <B>Cat. No. WH0010290M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~38.17 kDa using immunogen protein lysate.

Anti-SPEG antibody produced in rabbit - HPA018904 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPEG: <B>Cat. No. HPA018904</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human heart muscle shows strong membranous and cytoplasmic positivity in myocytes.

APEG1-Antibody-monoclonal-M01 - AT1159a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C2-2C7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (38.17 KDa) .

APEG1--SPEG-Antibody-internal-region - AF3770a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

APEG1 antibody - GTX108343 from GeneTex

Host Rabbit
Clonality Polyclonal

APEG1 antibody [N1], N-term - GTX108309 from GeneTex

Host Rabbit
Clonality Polyclonal

Goat anti-APEG1 / SPEG middle region Antibody (OAEB02959) - OAEB02959 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-APEG1 Antibody - AC21-2675 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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