Gene Symbol | MED18 |
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Entrez Gene | 54797 |
Alt Symbol | p28b |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 18 |
Other Description | TRAP/mediator complex subunit p28b|mediator of RNA polymerase II transcription subunit 18|mediator of RNA polymerase II transcription, subunit 18 homolog |
Swissprots | D3DPM1 Q9BUE0 Q9NXU9 |
Accessions | EAX07699 EAX07700 EAX07701 EAX07702 Q9BUE0 AB107222 BAD06869 AK000052 BAA90910 AK296130 BAG58875 BC002694 AAH02694 BG752399 DA090416 XM_005245914 XP_005245971 NM_001127350 NP_001120822 NM_017638 NP_060108 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Subcellular Location | Nucleus {ECO:0000305}. |
Med18 CRISPR/Cas9 KO Plasmid (h) - sc-407275 from Santa Cruz Biotechnology
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Med18 HDR Plasmid (h) - sc-407275-HDR from Santa Cruz Biotechnology
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Med18 Double Nickase Plasmid (h) - sc-407275-NIC from Santa Cruz Biotechnology
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Med18 Double Nickase Plasmid (h2) - sc-407275-NIC-2 from Santa Cruz Biotechnology
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Med18 CRISPR Activation Plasmid (h) - sc-407275-ACT from Santa Cruz Biotechnology
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Med18 CRISPR Activation Plasmid (h2) - sc-407275-ACT-2 from Santa Cruz Biotechnology
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Med18 Lentiviral Activation Particles (h) - sc-407275-LAC from Santa Cruz Biotechnology
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Med18 Lentiviral Activation Particles (h2) - sc-407275-LAC-2 from Santa Cruz Biotechnology
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Med18 siRNA (h) - sc-88848 from Santa Cruz Biotechnology
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Med18 shRNA Plasmid (h) - sc-88848-SH from Santa Cruz Biotechnology
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Med18 shRNA (h) Lentiviral Particles - sc-88848-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13167 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13167 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08145 from Sigma-Aldrich
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MED18 siRNA (Human) - CRJ0221 from Cohesion Biosciences
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shRNA set against Human MED18 (NM_017638.2) - SHH339955 from Creative biogene
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MED18 shRNA Plasmid (Human) - CHJ0221 from Cohesion Biosciences
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MED18 miRNA 3'UTR clone - MiUTR4H-TG05445 from Creative biogene
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