ZRANB3

Gene Symbol	ZRANB3
Entrez Gene	84083
Alt Symbol	4933425L19Rik, AH2
Species	Human
Gene Type	protein-coding
Description	zinc finger, RAN-binding domain containing 3
Other Description	DNA annealing helicase and endonuclease ZRANB3|annealing helicase 2|zinc finger Ran-binding domain-containing protein 3
Swissprots	D3DP76 B5MDI3 Q53SM1 B3KYA1 Q9H0E8 B4E375 Q5FWF4 E9PBP0 Q8N1P4 Q6P2C4
Accessions	AAX93066 AAY14765 EAX11629 EAX11630 EAX11631 EAX11632 EAX11633 EAX11634 EAX11635 EAX11636 Q5FWF4 AI670931 AK095362 BAC04536 AK131303 BAG54763 AK304601 BAG65387 AL136824 CAB66758 AL833322 AM392694 CAL37572 AM392702 CAL37580 BC089429 AAH89429 BX647838 XM_005263809 XP_005263866 XM_005263811 XP_005263868 XM_005263812 XP_005263869 XM_006712788 XP_006712851 XM_011511958 XP_011510260 XM_011511959 XP_011510261 XM_011511960 XP_011510262 XM_011511961 XP_011510263 XM_011511962 XP_011510264 XM_011511963 XP_011510265 XM_011511964 XP_011510266 XM_011511965 XP_011510267 XM_011511966 XP_011510268 XM_011511967 XP_011510269 NM_001286568 NP_001273497 NM_001286569 NP_001273498 NM_032143 NP_115519
Function	DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. {ECO:0000269|PubMed:21078962, ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634}.
Subcellular Location	Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZRANB3 fusion protein - ag18316 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ZRANB3 fusion protein - Ag19407 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Zinc finger Ran-binding domain-containing protein 3(ZRANB3) ,partial - CSB-YP705058HU CSB-EP705058HU CSB-BP705058HU CSB-MP705058HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Zinc finger Ran-binding domain-containing protein 3(ZRANB3) ,partial, Recombinant Protein - MBS1305203 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZRANB3 Protein - NBP2-13605PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ZRANB3 Protein - NBP2-13604PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ZRAB3-Antibody-Center-Blocking-peptide - BP10285c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZRANB3 Peptide, Human - M34GP18378H from Creative Peptides Category Peptide Source Synthetic. Species Human

ZRANB3 Recombinant Protein Antigen - NBP2-55227PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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