Gene Symbol | ALDH18A1 |
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Entrez Gene | 5832 |
Alt Symbol | ARCL3A, GSAS, P5CS, PYCS |
Species | Human |
Gene Type | protein-coding |
Description | aldehyde dehydrogenase 18 family, member A1 |
Other Description | aldehyde dehydrogenase family 18 member A1|delta-1-pyrroline-5-carboxylate synthase|delta-1-pyrroline-5-carboxylate synthetase|delta1-pyrroline-5-carboxlate synthetase|pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) |
Swissprots | Q5T566 B2R5Q4 P54886 Q3KQU2 D3DR44 B7Z5X8 Q9UM72 B7ZLP1 Q5T567 B7Z350 O95952 |
Accessions | EAW49994 EAW49995 EAW49996 EAW49997 P54886 AK126355 AK225455 AK225465 AK226032 AK295487 BAH12086 AK299557 BAH13064 AK312271 BAG35201 AW467503 BC106054 AAI06055 BC117240 AAI17241 BC117242 AAI17243 BC143930 AAI43931 BU170321 CD642171 HQ258499 ADR83253 U68758 AAD00169 U76542 AAD17454 X94453 CAA64224 XM_006717933 XP_006717996 XM_011540001 XP_011538303 NM_001017423 NP_001017423 NM_002860 NP_002851 |
Function | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761}. |
Subcellular Location | Mitochondrion inner membrane. |
Top Pathways | Arginine and proline metabolism, Biosynthesis of amino acids |
ALDH18A1 CRISPR/Cas9 KO Plasmid (h) - sc-406257 from Santa Cruz Biotechnology
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ALDH18A1 HDR Plasmid (h) - sc-406257-HDR from Santa Cruz Biotechnology
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ALDH18A1 Double Nickase Plasmid (h) - sc-406257-NIC from Santa Cruz Biotechnology
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ALDH18A1 Double Nickase Plasmid (h2) - sc-406257-NIC-2 from Santa Cruz Biotechnology
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ALDH18A1 CRISPR Activation Plasmid (h) - sc-406257-ACT from Santa Cruz Biotechnology
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ALDH18A1 CRISPR Activation Plasmid (h2) - sc-406257-ACT-2 from Santa Cruz Biotechnology
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ALDH18A1 Lentiviral Activation Particles (h) - sc-406257-LAC from Santa Cruz Biotechnology
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ALDH18A1 Lentiviral Activation Particles (h2) - sc-406257-LAC-2 from Santa Cruz Biotechnology
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ALDH18A1 siRNA (h) - sc-90408 from Santa Cruz Biotechnology
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ALDH18A1 shRNA Plasmid (h) - sc-90408-SH from Santa Cruz Biotechnology
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ALDH18A1 shRNA (h) Lentiviral Particles - sc-90408-V from Santa Cruz Biotechnology
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ALDH18A1 RNAi - H00005832-R03 from Novus Biologicals
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MISSION® esiRNA - EHU037001 from Sigma-Aldrich
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MISSION® siRNA - SIHK0106 from Sigma-Aldrich
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MISSION® siRNA - SIHK0107 from Sigma-Aldrich
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MISSION® siRNA - SIHK0104 from Sigma-Aldrich
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MISSION® siRNA - SIHK0103 from Sigma-Aldrich
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MISSION® siRNA - SIHK0108 from Sigma-Aldrich
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MISSION® siRNA - SIHK0105 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3043 from Sigma-Aldrich
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ALDH18A1 siRNA (Human) - CRH3944 from Cohesion Biosciences
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ALDH18A1 RNAi - H00005832-R04 from Novus Biologicals
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ALDH18A1 - MBS8226657 from MyBioSource
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shRNA set against Human ALDH18A1(NM_001017423.1) - SHG052129 from Creative biogene
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